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TBRG4 [mitochondrial matrix]
Stable Identifier
R-HSA-9837166
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
fullName evidence="9"FAST kinase domain-containing protein 4, FAKD4_HUMAN, FASTKD4
Locations in the PathwayBrowser for interactor UniProt:Q86X02 CDR2L
Expand all
Metabolism of RNA (Homo sapiens)
Mitochondrial RNA degradation (Homo sapiens)
FASTK family proteins regulate processing and stability of mitochondrial RNAs (Homo sapiens)
TBRG4 (FASTKD4) binds mitochondrial rRNAs and mRNAs (Homo sapiens)
TBRG4 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969Z0 TBRG4
Gene Names
TBRG4, CPR2, FASTKD4, KIAA0948
Chain
transit peptide:1-107, chain:108-631
Reference Genes
BioGPS Gene:9238 TBRG4
COSMIC (genes):TBRG4 TBRG4
CTD Gene:9238 TBRG4
dbSNP Gene:9238 TBRG4
ENSEMBL:ENSG00000136270 TBRG4
HGNC:17443 TBRG4
Monarch:9238 TBRG4
NCBI Gene:9238 TBRG4
OMIM:611325 TBRG4
UCSC:Q969Z0 TBRG4
Reference Transcript
RefSeq:NM_199122.2 TBRG4
RefSeq:NM_030900.3 TBRG4
RefSeq:NM_004749.3 TBRG4
Other Identifiers
11734700_a_at
11757139_x_at
11757174_x_at
17057433
17057460
17057462
17119670
220789_PM_s_at
220789_s_at
3049026
3049027
3049028
3049029
3049030
3049031
3049032
3049033
3049034
3049035
3049036
3049037
3049038
3049039
3049040
3049041
3049042
3049043
3049044
3049045
3049046
3049047
3049048
3049049
3049050
3049051
3049052
3049053
3049054
3049055
3049056
3049057
3049058
3049059
3049060
3049062
3049063
51855_at
8139468
8139482
8139484
8139486
9238
A_21_P0000301
A_21_P0000342
A_21_P0000343
A_23_P215658
GE54111
GO:0000963
GO:0003723
GO:0005515
GO:0005739
GO:0005759
GO:0008284
GO:0016071
GO:0035770
GO:0043226
GO:0044528
GO:0051726
GO:0090615
GO:0140053
HMNXSV003037093
HMNXSV003037606
HMNXSV003039132
ILMN_1783728
ILMN_1809047
ILMN_2414848
PH_hs_0028003
RNA33460|snoRNA_scaRNA_56_137
RNA33483|snoRNA_scaRNA_79_134
RNA33506|snoRNA_scaRNA_102_132
TC07001351.hg
TC07001352.hg
TC07001353.hg
g4758045_3p_s_at
Participates
as a component of
TBRG4:12S rRNA,16S rRNA, MT-ATP6 mRNA, MTCO1,2,3 mRNA,MT-CYB mRNA,MT-ND1,2,3,4,5,6 mRNA [mitochondrial matrix] (Homo sapiens)
as an input of
TBRG4 (FASTKD4) binds mitochondrial rRNAs and mRNAs (Homo sapiens)
Inferred To
Dmel\CG13850 [mitochondrial matrix]
(Drosophila melanogaster)
TBRG4 [mitochondrial matrix]
(Bos taurus)
TBRG4 [mitochondrial matrix]
(Canis familiaris)
TBRG4 [mitochondrial matrix]
(Gallus gallus)
TBRG4 [mitochondrial matrix]
(Plasmodium falciparum)
TBRG4 [mitochondrial matrix]
(Sus scrofa)
Homologues of TBRG4 [mitochondrial matrix]
(Plasmodium falciparum)
Tbrg4 [mitochondrial matrix]
(Mus musculus)
Tbrg4 [mitochondrial matrix]
(Rattus norvegicus)
tbrg4 [mitochondrial matrix]
(Danio rerio)
tbrg4 [mitochondrial matrix]
(Xenopus tropicalis)
fask-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000136270
ENSEMBL
ENSP00000420597
,
ENST00000258770
,
ENST00000361278
,
ENSP00000379016
,
ENST00000494076
,
ENSP00000354992
,
ENST00000395655
,
ENSP00000258770
HPA
ENSG00000136270-TBRG4
PRO
Q969Z0
Pharos - Targets
Q969Z0
GlyGen
Q969Z0
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52815 MRPL12
2
MRPL12 [mitochondrial inner membrane]
(R-HSA-5368256)
MRPL12 [mitochondrial matrix]
(R-HSA-9839674)
0.615
3
UniProt:Q9NRY5 FAM114A2
2
FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol]
(R-HSA-6802525)
FAM114A2(1-327)-BRAF(439-766) fusion [cytosol]
(R-HSA-6802321)
0.601
4
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q969L2 MAL2
0.556
3
UniProt:Q8IZR5-2 Q8IZR52
0.556
3
UniProt:Q86VR2 RETR3
0.556
3
UniProt:Q8TD16-2 BICD2
0.556
3
UniProt:Q8IZU0 FAM9B
0.556
3
UniProt:Q96D09 GASP2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q04118 PRB3
0.556
3
UniProt:Q9H400 LIME1
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q8WV19 SFT2A
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:Q9UBN6 TNFRSF10D
1
TNFRSF10D [plasma membrane]
(R-HSA-5633374)
0.556
3
UniProt:O15126 SCAMP1
2
SCAMP1 [plasma membrane]
(R-HSA-6806161)
SCAMP1 [specific granule membrane]
(R-HSA-6806140)
0.556
3
UniProt:B7ZLI8 B7ZLI8
0.556
3
UniProt:Q86X02 CDR2L
0.556
3
UniProt:Q8WW34-2 TMEM239
0.556
3
UniProt:Q8WZ55 BSND
1
BSND [plasma membrane]
(R-HSA-2854996)
0.556
3
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
0.556
3
UniProt:Q01151 CD83
0.527
2
UniProt:Q8TCS8 PNPT1
1
PNPT1 [mitochondrial matrix]
(R-HSA-9836559)
0.527
2
UniProt:A2RU67 F234B
0.527
4
UniProt:O95274 LYPD3
2
cleaved GPI-LYPD3 [extracellular region]
(R-HSA-8941013)
GPI-LYPD3 [plasma membrane]
(R-HSA-8940752)
0.527
3
UniProt:Q9P0K9 FRS1L
0.527
2
UniProt:Q9UQV4 LAMP3
0.527
3
UniProt:Q9H813 PACC1
0.527
2
UniProt:P32970 CD70
1
CD70 [plasma membrane]
(R-HSA-5667139)
0.527
3
UniProt:P41587 VIPR2
1
VIPR2 [plasma membrane]
(R-HSA-420227)
0.527
2
UniProt:Q96FM1 PGAP3
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
5
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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