Reactome | OPTN binds ATG9A

OPTN binds ATG9A

Stable Identifier

R-HSA-9840807

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, phagophore assembly site membrane

ReviewStatus

3/5

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During PINK1:PRKN-mediated mitophagy, the autophagy receptor optineurin (OPTN) forms a complex with the autophagy-related 9A (ATG9A) protein, a membrane-spanning protein that is recruited to the autophagosomal formation site (Yamamoto H et al., 2012; Yamano K et al., 2020). ATG9A localizes to the cytoplasmic single-membrane vesicles, termed ATG9 vesicles (Yamamoto H et al., 2012). OPTN recruits cytoplasmic ATG9A vesicles to damaged mitochondria (Yamano K et al., 2020), where these vesicles provide membrane contact sites delivering proteins and lipids during autophagosome formation (Yamamoto H et al., 2012; reviewed by Nishimura T & Tooze SA 2020). The leucine zipper domain of OPTN is required for the interaction with ATG9A (Yamano K et al., 2020). Disruptions of OPTN:ATG9A interaction inhibits mitophagy (Yamano K et al., 2020). Interactions between OPTN and other ATG proteins such as microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B or LC3) are implicated in autophagy.

Literature References

PubMed ID	Title	Journal	Year
32556086	Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy Hayashida, R, Kojima, W, Kikuchi, R, Demizu, Y, Kawawaki, J, Tanaka, K, Matsuda, N, Naito, M, Koyano, F, Shoda, T, Yamano, K	J Cell Biol	2020