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Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
Stable Identifier
R-HSA-9841849
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
fullName evidence="26"Forkhead box protein O3, FOXO3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Homo sapiens)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43524 FOXO3
Gene Names
FOXO3, FKHRL1, FOXO3A
Chain
chain:1-673
Reference Genes
BioGPS Gene:2309 FOXO3
COSMIC (genes):FOXO3 FOXO3
CTD Gene:2309 FOXO3
dbSNP Gene:2309 FOXO3
ENSEMBL:ENSG00000118689 FOXO3
ENSEMBL_homo_sapiens_GENE:ENSG00000118689.15 FOXO3
HGNC:3821 FOXO3
KEGG Gene (Homo sapiens):2309 FOXO3
Monarch:2309 FOXO3
NCBI Gene:2309 FOXO3
OMIM:602681 FOXO3
UCSC:O43524 FOXO3
Reference Transcript
RefSeq:XM_005266868.3 FOXO3
RefSeq:XM_011535629.2 FOXO3
RefSeq:NM_201559.2 FOXO3
RefSeq:XM_011535628.2 FOXO3
RefSeq:NM_001455.3 FOXO3
RefSeq:XM_017010586.1 FOXO3
Other Identifiers
11718890_x_at
11718891_s_at
11718892_s_at
11737906_x_at
11746522_s_at
11746523_x_at
11749812_s_at
11755663_s_at
204131_PM_s_at
204131_s_at
204132_PM_s_at
204132_s_at
210655_PM_s_at
210655_s_at
217399_3p_s_at
217399_PM_s_at
217399_s_at
224889_3p_at
224889_PM_at
224889_at
224891_PM_at
224891_at
2309
2920476
2920477
2920478
2920479
2920480
2920481
2920482
2920483
2920484
2920485
2920486
2920537
2920538
2920541
2920542
2920543
2920556
2920567
2920568
2920570
2920572
2920574
2920575
34740_at
3748537
3748538
3748557
3748558
3748560
3748563
3748564
3748565
3748566
3748567
3748568
3748569
3748570
47893_s_at
49469_at
49651_at
8013307
8121365
A_23_P345575
A_32_P102062
A_33_P3240392
A_33_P3375665
GE54251
GE85764
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001227
GO:0001228
GO:0001542
GO:0001544
GO:0001547
GO:0001556
GO:0002376
GO:0003012
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005759
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006390
GO:0006417
GO:0006914
GO:0006915
GO:0007155
GO:0008013
GO:0009410
GO:0010508
GO:0012501
GO:0014737
GO:0016020
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030330
GO:0030336
GO:0031490
GO:0031667
GO:0032991
GO:0033209
GO:0034246
GO:0034599
GO:0042149
GO:0042593
GO:0042594
GO:0043065
GO:0043226
GO:0043525
GO:0043565
GO:0045591
GO:0045648
GO:0045665
GO:0045893
GO:0045944
GO:0048854
GO:0048856
GO:0048870
GO:0060070
GO:0070542
GO:0071333
GO:0071386
GO:0071456
GO:0071548
GO:0090090
GO:0090571
GO:0097150
GO:0097192
GO:0140053
GO:0140110
GO:1901300
GO:1902895
GO:1903428
GO:1904646
GO:1990090
GO:1990785
GO:1990837
GO:2000177
GO:2000353
GO:2000377
HMNXSV003035668
Hs.14845.0.A2_3p_a_at
Hs.214783.0.S1_3p_at
Hs.214783.0.S1_3p_x_at
Hs.214783.0.S2_3p_at
Hs.274468.0.S1_3p_s_at
ILMN_1681703
ILMN_1687940
ILMN_1712515
ILMN_1844692
PH_hs_0028777
PH_hs_0033951
TC06000868.hg
TC06002977.hg
g4106722_3p_a_at
Participates
as an input of
SIRT3 deacetylates Ac-K272,K290-FOXO3 (Homo sapiens)
Other forms of this molecule
p-S215 FOXO3 [nucleoplasm]
p-S215 FOXO3 [cytosol]
FOXO3 [cytosol]
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
p-S43,S173,S294,S325-FOXO3 [cytosol]
FOXO3(?-673) [mitochondrial matrix]
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
p-T32,S253,S315-FOXO3 [cytosol]
p-T32,S253,S315-FOXO3 [nucleoplasm]
FOXO3 [nucleoplasm]
Inferred To
Foxo3 [mitochondrial matrix]
(Mus musculus)
Foxo3 [mitochondrial matrix]
(Rattus norvegicus)
foxo3 [mitochondrial matrix]
(Xenopus tropicalis)
daf-16 [mitochondrial matrix]
(Caenorhabditis elegans)
foxo3b [mitochondrial matrix]
(Danio rerio)
FOXO3 [mitochondrial matrix]
(Bos taurus)
FOXO3 [mitochondrial matrix]
(Canis familiaris)
FOXO3 [mitochondrial matrix]
(Gallus gallus)
FOXO3 [mitochondrial matrix]
(Sus scrofa)
foxo [mitochondrial matrix]
(Drosophila melanogaster)
Modified Residues
Name
N6-acetyl-L-lysine at 271
Coordinate
271
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 290
Coordinate
290
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
XP_016866075.1
,
XP_005266925.1
,
XP_011533931.1
,
NP_001446.1
,
NP_963853.1
,
XP_011533930.1
OpenTargets
ENSG00000118689
HPA
ENSG00000118689-FOXO3
GeneCards
O43524
Ensembl
ENSP00000446316
,
ENST00000406360
,
ENSP00000339527
,
ENSP00000385824
,
ENST00000343882
,
ENST00000540898
,
ENSG00000118689
PRO
O43524
Pharos - Targets
O43524
PDB
6MNL
,
7V9B
,
2UZK
,
2K86
,
2LQH
,
2LQI
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.851
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.774
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.774
6
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.743
9
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.706
5
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.704
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.695
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.692
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.667
5
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.632
7
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.615
3
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.591
4
IntAct:EBI-1767788 BIM
0.59
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
3
UniProt:Q60987 Foxg1
2
Foxg1 [nucleoplasm]
(R-MMU-9022630)
Foxg1 [nucleoplasm]
(R-MMU-9022629)
0.544
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.536
2
IntAct:EBI-1657542 ERALPHA
0.527
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.524
3
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.499
3
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
2
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.499
2
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.499
2
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.499
2
UniProt:O75529 TAF5L
1
TAF5L [nucleoplasm]
(R-HSA-212336)
0.499
2
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.499
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
3
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.462
2
IntAct:EBI-2891650 CDKN1B
0.462
2
IntAct:EBI-2678752 ANDR
0.462
2
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