Reactome | TNK2 [cytosol]

TNK2 [cytosol]

Stable Identifier

R-HSA-9842568

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Activated CDC42 kinase 1, ACK1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q07912 TNK2

Gene Names

TNK2, ACK1

Chain

chain:1-1038

Reference Genes

BioGPS Gene:10188 TNK2

COSMIC (genes):TNK2 TNK2

CTD Gene:10188 TNK2

dbSNP Gene:10188 TNK2

ENSEMBL:ENSG00000061938 TNK2

HGNC:19297 TNK2

KEGG:hsa:10188 TNK2

Monarch:10188 TNK2

NCBI Gene:10188 TNK2

OMIM:606994 TNK2

UCSC:Q07912 TNK2

Reference Transcript

Participates

as a component of

GRB2:TNK2 [cytosol] (Homo sapiens)

Inferred To

ripk1 [cytosol] (Xenopus tropicalis)

TNK2 [cytosol] (Gallus gallus)

TNK2 [cytosol] (Mus musculus)

TNK2 [cytosol] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2246

OpenTargets

ENSG00000061938

ENSEMBL

ENSP00000329425, ENSP00000395588, ENST00000671753, ENSG00000061938, ENST00000439230, ENSP00000499858, ENST00000333602

ZINC - FDA approved

ACK1_HUMAN

ZINC - Substances

ACK1_HUMAN

ZINC - Biogenic

ACK1_HUMAN

ZINC target

Q07912

PRO

Q07912

GlyGen

Q07912

PDB

8HMT, 5ZXB, 8THA, 4HZS, 6VQM, 3EQR, 8FZ3, 7KP6, 1CF4, 1U46, 1U54, 4EWH, 8Q5P, 4ID7, 8FE9, 1U4D, 4HZR, 3EQP

ZINC - Investigational

ACK1_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000061938-TNK2

GeneCards

TNK2

Pharos - Targets

Q07912

Orphanet

TNK2

ZINC - Predictions - Purchasable

ACK1_HUMAN

HMDB Protein

HMDBP01350

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.737	5
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.688	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	3
UniProt:P07902 GALT	4	GALT Q188R [cytosol] (R-HSA-5610008) GALT K285N [cytosol] (R-HSA-5610009) GALT S135L [cytosol] (R-HSA-5610004) GALT [cytosol] (R-HSA-70356)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P56945 BCAR1	4	BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.524	5
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.488	2

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