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me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
Stable Identifier
R-HSA-9843959
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
34794168
Genome surveillance by HUSH-mediated silencing of intronless mobile elements
Cuesta, SM
,
Seczynska, M
,
Bloor, S
,
Lehner, PJ
Nature
2022
Participants
components
HUSH complex:L1 RNA [nucleoplasm]
(Homo sapiens)
me3-K16-ATF7IP:SETDB1 [nucleoplasm]
(Homo sapiens)
MORC2 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)
Inferred To
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Bos taurus)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Canis familiaris)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Danio rerio)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Gallus gallus)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Rattus norvegicus)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
(Sus scrofa)
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