SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)

Stable Identifier
R-HSA-9844006
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SETDB1 tethered to retroelement nascent RNA via the HUSH complex trimethylates lysine-9 of histone H3 in nucleosomes of retroelement chromatin (Seczynska et al. 2022).
Literature References
PubMed ID Title Journal Year
34794168 Genome surveillance by HUSH-mediated silencing of intronless mobile elements

Cuesta, SM, Seczynska, M, Bloor, S, Lehner, PJ

Nature 2022
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Catalyst Activity

histone H3 methyltransferase activity of me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]

Orthologous Events
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