SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome

Stable Identifier
R-HSA-9844057
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SETDB1 bound to the HUSH complex via ATF7IP (Timms et al. 2016) trimethylates lysine-9 of histone H3 (H3K9). By binding trimethylated H3K9 on one nucleosome and recruiting SETDB1 to trimethylate H3K9 on an adjacent nucleosome, the HUSH complex causes heterochromatin spreading (Tchasovnikarova et al. 2015, Seczynska et al. 2022).
Literature References
PubMed ID Title Journal Year
29211708 Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

Gu, B, Swigut, T, Bassik, MC, Grow, E, Liu, N, Lee, CH, Wysocka, J

Nature 2018
34794168 Genome surveillance by HUSH-mediated silencing of intronless mobile elements

Cuesta, SM, Seczynska, M, Bloor, S, Lehner, PJ

Nature 2022
27732843 ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

Dougan, G, Tchasovnikarova, IA, Timms, RT, Lehner, PJ, Antrobus, R

Cell Rep 2016
26022416 GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Dougan, G, Timms, RT, Tchasovnikarova, IA, Göttgens, B, Matheson, NJ, Wals, K, Lehner, PJ, Dawson, MA, Antrobus, R

Science 2015
Participants
Participates
Catalyst Activity

histone H3 methyltransferase activity of me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm]

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