Reactome | SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome

SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome

Stable Identifier

R-HSA-9844057

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome

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SETDB1 bound to the HUSH complex via ATF7IP (Timms et al. 2016) trimethylates lysine-9 of histone H3 (H3K9). By binding trimethylated H3K9 on one nucleosome and recruiting SETDB1 to trimethylate H3K9 on an adjacent nucleosome, the HUSH complex causes heterochromatin spreading (Tchasovnikarova et al. 2015, Seczynska et al. 2022).

Literature References

PubMed ID	Title	Journal	Year
29211708	Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators Liu, N, Lee, CH, Swigut, T, Grow, E, Gu, B, Bassik, MC, Wysocka, J	Nature	2018
34794168	Genome surveillance by HUSH-mediated silencing of intronless mobile elements Seczynska, M, Bloor, S, Cuesta, SM, Lehner, PJ	Nature	2022
27732843	ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex Timms, RT, Tchasovnikarova, IA, Antrobus, R, Dougan, G, Lehner, PJ	Cell Rep	2016
26022416	GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells Tchasovnikarova, IA, Timms, RT, Matheson, NJ, Wals, K, Antrobus, R, Göttgens, B, Dougan, G, Dawson, MA, Lehner, PJ	Science	2015