Kinesin-5 is a homotetramer

Stable Identifier
R-HSA-984606
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Kinesin-5 motors are bipolar homotetramers with two motor domains at each end, separated by a stalk/tail region (Cole et al. 1994). During mitosis, Kinesin-5 motors function near the spindle midzone to maintain pole to pole distance. Motor domains attach to microtubules from opposite poles and translocate towards the plus ends, thereby pushing the spindle poles apart (Kapitein et al. 2005). Kinesin-5 is also involved in axon growth (Myers & Baas 2007).

Literature References
PubMed ID Title Journal Year
8548803 Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Blangy, A, Lane, HA, d'Hérin, P, Harper, M, Kress, M, Nigg, EA

Cell 1995
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