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Kinesin-5 is a homotetramer
Stable Identifier
R-HSA-984606
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Kinesins (Homo sapiens)
Kinesin-5 is a homotetramer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Kinesin-5 motors are bipolar homotetramers with two motor domains at each end, separated by a stalk/tail region (Cole et al. 1994). During mitosis, Kinesin-5 motors function near the spindle midzone to maintain pole to pole distance. Motor domains attach to microtubules from opposite poles and translocate towards the plus ends, thereby pushing the spindle poles apart (Kapitein et al. 2005). Kinesin-5 is also involved in axon growth (Myers & Baas 2007).
Literature References
PubMed ID
Title
Journal
Year
8548803
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
Kress, M
,
Nigg, EA
,
Lane, HA
,
Blangy, A
,
Harper, M
,
d'Hérin, P
Cell
1995
Participants
Input
x 4
KIF11 [cytosol]
(Homo sapiens)
Output
Kinesin-5 homotetramer [cytosol]
(Homo sapiens)
Participates
as an event of
Kinesins (Homo sapiens)
Orthologous Events
Kinesin-5 is a homotetramer (Bos taurus)
Kinesin-5 is a homotetramer (Caenorhabditis elegans)
Kinesin-5 is a homotetramer (Canis familiaris)
Kinesin-5 is a homotetramer (Dictyostelium discoideum)
Kinesin-5 is a homotetramer (Drosophila melanogaster)
Kinesin-5 is a homotetramer (Gallus gallus)
Kinesin-5 is a homotetramer (Mus musculus)
Kinesin-5 is a homotetramer (Plasmodium falciparum)
Kinesin-5 is a homotetramer (Rattus norvegicus)
Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)
Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)
Kinesin-5 is a homotetramer (Sus scrofa)
Kinesin-5 is a homotetramer (Xenopus tropicalis)
Authored
Akkerman, JW (2010-10-29)
Reviewed
Ouwehand, WH (2010-11-12)
Created
Jupe, S (2010-11-02)
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