Reactome: A Curated Pathway Database

Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin

Stable Identifier
R-HSA-984648
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytokinesis requires the central spindle, which forms during anaphase by the bundling of antiparallel nonkinetochore microtubules. Microtubule bundling and completion of cytokinesis require MKLP1, a kinesin-6 family member, and RACGAP1 (MgcRacGap), which contains a RhoGAP domain. These form a heterotetrameric complex known as centralspindlin. Centralspindlin, but not its individual components, strongly promotes microtubule bundling in vitro.

Literature References
Participants
Participant Of
hasEvent
Orthologous Events