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Kinesin-7 is a dimer

Stable Identifier
R-HSA-984689
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Human kinesin-7, or CENP-E was one of the first kinesins to be discovered (Yen et al. 1991). It is essential for mammalian development, having a role in stabilizing kinetochore-microtubule capture (Putkey et al. 2002), CENP-E is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules and localizes to kinetochores throughout all phases of mitotic chromosome movement (early premetaphase through anaphase A). Though originally reported to be minus-end-directed it is now believed to be a plus-end-directed dimeric kinesin (Espeut et al. 2008). It is sequestered in the cytoplasm until nuclear envelope breakdown and then localizes to its chromosomal cargo at the kinetochores (Brown et al. 1996).

Literature References
PubMed ID Title Journal Year
18342609 Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E Mol Cell 2008
Participants
Participant Of
hasEvent
Orthologous Events