Kinesin-3 is a dimer

Stable Identifier
R-HSA-984733
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Kinesin-3 drives the transport of synaptic vesicle precursors to axon terminals. Loss of the Caenorhabditis elegans protein Unc104, eqivalent to human KIF1A, results in decreased synaptic vesicles in axonal growth cones. In mice loss of KIF1A caused severe motor and sensory abnormalities associated with neuronal cell death (Yonekawa et al. 1998). Kinesin-3 is often described as monomeric, but has recently been shown to be functionally dimeric (Hammond et al. 2009).

Literature References
PubMed ID Title Journal Year
19338388 Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition

Hammond, JW, Cai, D, Blasius, TL, Li, Z, Jiang, Y, Jih, GT, Meyhofer, E, Verhey, KJ

PLoS Biol 2009
7528108 KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria

Nangaku, M, Sato-Yoshitake, R, Okada, Y, Noda, Y, Takemura, R, Yamazaki, H, Hirokawa, N

Cell 1994
7539720 The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors

Okada, Y, Yamazaki, H, Sekine-Aizawa, Y, Hirokawa, N

Cell 1995
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