p-Y223,Y551-BTK [plasma membrane]

Stable Identifier
R-HSA-984807
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BTK phosphorylated at Tyr-223 and Tyr-551, Tyrosine-protein kinase BTK, BTK_HUMAN, BTK
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON

Immunity 1996
17264076 Activation mechanism and steady state kinetics of Bruton's tyrosine kinase

Dinh, M, Grunberger, D, Ho, H, Tsing, SY, Shaw, D, Lee, S, Barnett, J, Hill, RJ, Swinney, DC, Bradshaw, JM

J Biol Chem 2007
External Reference Information
External Reference
UniProt:Q06187 BTK
Gene Names
BTK, AGMX1, ATK, BPK
Chain
initiator methionine:1, chain:2-659
Reference Genes
BioGPS Gene:695 BTK
COSMIC (genes):BTK BTK
CTD Gene:695 BTK
dbSNP Gene:695 BTK
ENSEMBL:ENSG00000010671 BTK
HGNC:1133 BTK
KEGG Gene (Homo sapiens):695 BTK
Monarch:695 BTK
NCBI Gene:695 BTK
OMIM:300300 BTK
UCSC:Q06187 BTK
Reference Transcript
Other Identifiers
04660+2.7.10.2
11730847_a_at
11756709_x_at
1198
16689
17112735
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2028
205504_at
2GE9
2Z0P
38213_at
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4015705
4015710
4015711
4015713
4015714
4015716
4015718
4015720
4015721
4015724
4015729
4015730
4015731
4015732
4015733
4015734
4015735
4015736
4015738
4015741
4015743
4015745
4015746
4015751
4015752
4015755
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5XYZ
5ZZ4
695
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
8174051
A_23_P137139
A_33_P3277514
AAA61479
AAB60639
AAB64205
AAC51347
AAI09080
AAI09081
AK314382
AL035422
BAG37008
BC109079
BC109080
BTK
BTK-201
BTK-210
CAA41728
CAB016689
CCDS14482
CCDS76003
ENSG00000010671
ENSP00000308176
ENSP00000483570
ENST00000308731
ENST00000308731.7
ENST00000621635
ENST00000621635.4
EntrezGene:695
EntrezGene:BTK
g4557376_3p_at
GE61511
GO:0000166
GO:0001805
GO:0001812
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0002553
GO:0002721
GO:0002755
GO:0002902
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005547
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0007165
GO:0007186
GO:0007249
GO:0007267
GO:0007498
GO:0008150
GO:0008219
GO:0008283
GO:0008289
GO:0009058
GO:0010033
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019722
GO:0021700
GO:0030154
GO:0030889
GO:0031410
GO:0034614
GO:0034641
GO:0035556
GO:0038083
GO:0038095
GO:0042113
GO:0042629
GO:0042802
GO:0043167
GO:0043226
GO:0045087
GO:0045121
GO:0045579
GO:0046777
GO:0046872
GO:0048469
GO:0048471
GO:0048856
GO:0050852
GO:0050853
GO:0051092
GO:0071226
GO:0097190
GO:0098761
HGNC:1133
HPA001198
HPA002028
ILMN_1662026
IPR000719
IPR000980
IPR001245
IPR001452
IPR001562
IPR001849
IPR008266
IPR011009
IPR011993
IPR017441
IPR020635
IPR035574
IPR036028
IPR036860
L31557
L31558
L31559
L31561
L31563
L31564
L31565
L31566
L31567
L31568
L31569
L31570
L31571
L31572
LRG_128
LRG_128t1
MIM:300300
MIM:300755
MIM:307200
NM_000061
NM_001287344
NP_000052
NP_001274273
PF00017
PF00018
PF00169
PF00779
PF07714
PH_hs_0009711
PR00109
PR00401
PR00402
PR00452
Q5JY90
SM00107
SM00219
SM00233
SM00252
SM00326
TC0X001218.hg
TC0X002155.hg
U10084
U10085
U10086
U10087
U13410
U13412
U13413
U13414
U13415
U13416
U13417
U13422
U13423
U13424
U13425
U13427
U13428
U13429
U13430
U13431
U13432
U13433
U3NG26
U78027
U78027_rna4_at
UPI0000126B16
UPI000021216F
X58957
Participant Of
hasComponent
Other forms of this molecule
Active BTK [cytosol]
p-Y223,Y551-BTK [cytosol]
p-Y551-BTK [cytosol]
p-Y551-BTK [plasma membrane]
BTK [cytosol]
Inferred To
phospho-p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
phospho-p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
phospho-p-Y223,Y551-BTK [plasma membrane] (Danio rerio)
phospho-p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
phospho-p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
phospho-p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
phospho-p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 223
Coordinate
223
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 551
Coordinate
551
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (15)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P78347 GTF2I      0.724 6
 UniProt:Q8WV28 BLNK  2 0.667 4
 IntAct:EBI-1521221      0.633 4
 UniProt:Q06187 BTK  6 0.623 3
 UniProt:Q99856 ARID3A  1 0.558 3
 UniProt:P21145 MAL      0.556 5
 UniProt:P50222 MEOX2      0.556 3
 UniProt:P62993 GRB2  1 0.547 2
 UniProt:O60239 3BP5      0.524 4
 UniProt:P08238 HSP90AB1  6 0.524 2
 UniProt:Q04759 PRKCQ  9 0.524 2
 ChEBI:39112 BOSUTINIB      0.499 2
 ChEBI:49375 DASATINIB      0.499 2
 UniProt:Q92569 PIK3R3  2 0.488 2
 UniProt:Q9P2D0 IBTK      0.463 2