Reactome | p-Y223,Y551-BTK [plasma membrane]

p-Y223,Y551-BTK [plasma membrane]

Stable Identifier

R-HSA-984807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

BTK phosphorylated at Tyr-223 and Tyr-551, Tyrosine-protein kinase BTK, BTK_HUMAN, BTK

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
17264076	Activation mechanism and steady state kinetics of Bruton's tyrosine kinase Dinh, M, Grunberger, D, Ho, H, Tsing, SY, Shaw, D, Lee, S, Barnett, J, Hill, RJ, Swinney, DC, Bradshaw, JM	J Biol Chem	2007
8630736	Regulation of Btk function by a major autophosphorylation site within the SH3 domain Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON	Immunity	1996

External Reference Information

External Reference

UniProt:Q06187 BTK

Gene Names

BTK, AGMX1, ATK, BPK

Chain

initiator methionine:1, chain:2-659

Reference Genes

BioGPS Gene:695 BTK

COSMIC (genes):BTK BTK

CTD Gene:695 BTK

dbSNP Gene:695 BTK

ENSEMBL:ENSG00000010671 BTK

HGNC:1133 BTK

KEGG:hsa:695 BTK

Monarch:695 BTK

NCBI Gene:695 BTK

OMIM:300300 BTK

UCSC:Q06187 BTK

Reference Transcript

Other Identifiers

11730847_a_at

11735122_at

11756709_x_at

17112729

17112735

205504_PM_at

205504_at

38213_at

4015701

4015702

4015703

4015704

4015705

4015710

4015711

4015712

4015713

4015714

4015715

4015716

4015717

4015718

4015719

4015720

4015721

4015722

4015723

4015724

4015728

4015729

4015730

4015731

4015732

4015733

4015734

4015735

4015736

4015738

4015739

4015741

4015743

4015744

4015745

4015746

4015747

4015751

4015752

4015753

4015754

4015755

695

71820_at

8174047

8174051

ADDON002881.hg

A_23_P137139

A_23_P358417

A_33_P3277514

GE61511

GE63153

GO:0000166

GO:0001780

GO:0001805

GO:0001812

GO:0001818

GO:0002250

GO:0002344

GO:0002376

GO:0002553

GO:0002639

GO:0002721

GO:0002755

GO:0002902

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005547

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006468

GO:0006915

GO:0007498

GO:0008270

GO:0008289

GO:0016004

GO:0016020

GO:0016301

GO:0016740

GO:0018108

GO:0019722

GO:0030163

GO:0030167

GO:0030889

GO:0030890

GO:0031410

GO:0032481

GO:0032496

GO:0032693

GO:0032755

GO:0032760

GO:0034614

GO:0035556

GO:0038095

GO:0042113

GO:0042802

GO:0043123

GO:0043274

GO:0045087

GO:0045121

GO:0045579

GO:0046872

GO:0048469

GO:0048471

GO:0048856

GO:0050766

GO:0050852

GO:0050853

GO:0050864

GO:0050869

GO:0051092

GO:0061516

GO:0070664

GO:0071226

GO:0097190

GO:0098542

GO:0098761

GO:0098772

GO:0140096

GO:0140896

GO:0141111

GO:0150153

GO:1900227

GO:1901135

GO:1901647

GO:1990959

HMNXSV003005100

HMNXSV003032904

ILMN_1662026

PH_hs_0009711

TC0X001217.hg

TC0X001218.hg

TC0X002155.hg

U78027_rna4_at

g4557376_3p_at

Participates

as a component of

p-Y223,551-BTK:PIP3 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y551-BTK [plasma membrane]

BTK [cytosol]

p-Y551-BTK [cytosol]

p-Y223,Y551-BTK [cytosol]

Active BTK [cytosol]

Inferred To

phospho-BTK [plasma membrane] (Bos taurus)

phospho-BTK [plasma membrane] (Gallus gallus)

phospho-BTK [plasma membrane] (Sus scrofa)

phospho-Btk [plasma membrane] (Mus musculus)

phospho-Btk [plasma membrane] (Rattus norvegicus)

phospho-p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)

Modified Residues

Name

O4'-phospho-L-tyrosine at 223

Coordinate

223

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 551

Coordinate

551

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_000052.1, NP_001274274.1, NP_001274273.1

ZINC - World Drugs

BTK_HUMAN

Guide to Pharmacology - Targets

1948

ENSEMBL

ENSP00000512054, ENSP00000512053, ENST00000695615, ENST00000695614, ENSP00000483570, ENST00000621635, ENSG00000010671, ENSP00000308176, ENST00000308731

OpenTargets

ENSG00000010671

ZINC - FDA approved

BTK_HUMAN

ZINC - Substances

BTK_HUMAN

ZINC - Biogenic

BTK_HUMAN

ZINC target

Q06187

PRO

Q06187

GlyGen

Q06187

PDB

6TFP, 6DI0, 4OTR, 6W8I, 6TT2, 8EJB, 6OMU, 6HRP, 8TU3, 5BPY, 6NFH, 8DSO, 7KXL, 5BQ0, 7N5X, 3PJ1, 7KXP, 3K54, 6AUB, 7R60, 1AWX, 1B55, 6E4F, 5FBO, 7N4Q, 5P9J, 5XYZ, 6BKW, 5P9I, 6X3P, 6YYG, 5P9F, 6S90, 4OTQ, 4Z3V, 6BLN, 1BWN, 8FLG, 1BTK, 6HRT, 5J87, 6TUH, 4RFZ, 3PIY, 7KXN, 7N5O, 7KXM, 6EP9, 4NWM, 4YHF, 1K2P, 3GEN, 6BIK, 6NZM, 5P9L, 4OT6, 6VXQ, 5P9K, 6YYK, 8GC7, 7N4R, 6W07, 7LTY, 6X3O, 4ZLZ, 8GC8, 6BKH, 8E2M, 4OTF, 8U2D, 5VFI, 8FLL, 3OCT, 4RX5, 3PIZ, 8TU4, 6AUA, 6XE4, 3PJ3, 4RFY, 3PIX, 7KXO, 7L5O, 7N5Y, 7R61, 6N9P, 8FLV, 7KXQ, 2Z0P, 5KUP, 5P9M, 4OT5, 7YC9, 6BKE, 5FBN, 8YVV, 6DI9, 5P9H, 6J6M, 4ZLY, 6DI1, 6W06, 6DI3, 8U2E, 5P9G, 3P08, 1QLY, 8FLH, 8FLN, 3OCS, 6NFI, 5ZZ4, 7L5P, 8TU5, 3PJ2, 5U9D, 5VGO, 4RG0, 6TVN, 7N5R, 6HTF, 1AWW, 7N4S, 6W7O, 7LTZ, 5T18, 5JRS, 6X3N, 6TSE, 6O8I, 6YYF, 6DI5, 2GE9

ZINC - Investigational

BTK_HUMAN

GeneCards

BTK

HPA

ENSG00000010671-BTK

Pharos - Targets

Q06187

Orphanet

BTK

ZINC - Predictions - Purchasable

BTK_HUMAN

HMDB Protein

HMDBP01420

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NXT1 ANR54			0.725	5
UniProt:P78347 GTF2I			0.724	6
UniProt:Q8WV28 BLNK	2	BLNK [cytosol] (R-HSA-912750) p-5Y-BLNK [plasma membrane] (R-HSA-983579)	0.667	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.641	3
IntAct:EBI-1521221			0.633	4
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) p-Y551-BTK [plasma membrane] (R-HSA-9606165) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323)	0.623	3
UniProt:Q9BVA0 KTNB1			0.589	2
UniProt:Q99856 ARID3A	1	ARID3A [nucleoplasm] (R-HSA-3782552)	0.558	3
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.558	2
UniProt:P50222 MEOX2			0.556	3
UniProt:P21145 MAL			0.556	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:Q9Y6R4 M3K4			0.527	2
UniProt:Q8N5M4 TTC9C			0.527	2
UniProt:Q04759 PRKCQ	9	p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-202152) p-Y90-PRKCQ [plasma membrane] (R-HSA-202395) PRKCQ [plasma membrane] (R-HSA-202346) PRKQC closed conformation [cytosol] (R-HSA-202185) PRKCQ [cytosol] (R-HSA-58216) PRKCQ(355-706) [cytosol] (R-HSA-212514) PRKCQ(1-354) [cytosol] (R-HSA-212526) p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-HSA-2685606) PRKCQ [photoreceptor disc membrane] (R-HSA-2648997)	0.524	2
UniProt:O60239 3BP5			0.524	4
ChEBI:49375 DASATINIB			0.499	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2
UniProt:Q9P2D0 IBTK			0.463	2