p-Y223,Y551-BTK [plasma membrane]

Stable Identifier
R-HSA-984807
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BTK phosphorylated at Tyr-223 and Tyr-551, Tyrosine-protein kinase BTK, BTK_HUMAN, BTK
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON

Immunity 1996
17264076 Activation mechanism and steady state kinetics of Bruton's tyrosine kinase

Dinh, M, Grunberger, D, Ho, H, Tsing, SY, Shaw, D, Lee, S, Barnett, J, Hill, RJ, Swinney, DC, Bradshaw, JM

J Biol Chem 2007
External Reference Information
External Reference
UniProt:Q06187 BTK
Gene Names
BTK, AGMX1, ATK, BPK
Chain
initiator methionine:1, chain:2-659
Reference Genes
BioGPS Gene:695 BTK
COSMIC (genes):BTK BTK
CTD Gene:695 BTK
dbSNP Gene:695 BTK
ENSEMBL:ENSG00000010671 BTK
HGNC:1133 BTK
KEGG Gene (Homo sapiens):695 BTK
Monarch:695 BTK
NCBI Gene:695 BTK
OMIM:300300 BTK
UCSC:Q06187 BTK
Reference Transcript
Other Identifiers
11730847_a_at
11756709_x_at
17112735
205504_at
38213_at
4015705
4015710
4015711
4015713
4015714
4015716
4015718
4015720
4015721
4015724
4015729
4015730
4015731
4015732
4015733
4015734
4015735
4015736
4015738
4015741
4015743
4015745
4015746
4015751
4015752
4015755
695
8174051
A_23_P137139
A_33_P3277514
GE61511
GO:0000166
GO:0001805
GO:0001812
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0002553
GO:0002721
GO:0002755
GO:0002902
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005547
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006915
GO:0006950
GO:0007165
GO:0007186
GO:0007249
GO:0007267
GO:0007498
GO:0008150
GO:0008219
GO:0008283
GO:0008289
GO:0009058
GO:0010033
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019722
GO:0021700
GO:0030154
GO:0030889
GO:0031410
GO:0034614
GO:0034641
GO:0035556
GO:0038095
GO:0042113
GO:0042629
GO:0042802
GO:0043167
GO:0043226
GO:0045087
GO:0045121
GO:0045579
GO:0046777
GO:0046872
GO:0048469
GO:0048471
GO:0048856
GO:0050853
GO:0051092
GO:0071226
GO:0097190
GO:0098761
ILMN_1662026
PH_hs_0009711
TC0X001218.hg
TC0X002155.hg
U78027_rna4_at
g4557376_3p_at
Participant Of
hasComponent
Other forms of this molecule
Active BTK [cytosol]
p-Y551-BTK [cytosol]
p-Y223,Y551-BTK [cytosol]
p-Y551-BTK [plasma membrane]
BTK [cytosol]
Inferred To
Homologues of p-Y223,Y551-BTK [plasma membrane] (Danio rerio)
phospho-BTK [plasma membrane] (Canis familiaris)
phospho-BTK [plasma membrane] (Sus scrofa)
phospho-Btk [plasma membrane] (Mus musculus)
phospho-Btk [plasma membrane] (Rattus norvegicus)
phospho-p-Y223,Y551-BTK [plasma membrane] (Bos taurus)
phospho-btk [plasma membrane] (Danio rerio)
phospho-btk [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 223
Coordinate
223
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 551
Coordinate
551
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P78347 GTF2I      0.724 6
 UniProt:Q8WV28 BLNK  2 0.667 4
 IntAct:EBI-1521221      0.633 4
 UniProt:Q06187 BTK  6 0.623 3
 UniProt:Q13444 ADAM15  1 0.558 2
 UniProt:Q99856 ARID3A  1 0.558 3
 UniProt:P21145 MAL      0.556 5
 UniProt:P50222 MEOX2      0.556 3
 UniProt:P62993 GRB2  1 0.547 2
 UniProt:O60239 3BP5      0.524 4
 UniProt:Q04759 PRKCQ  9 0.524 2
 UniProt:P08238 HSP90AB1  6 0.524 2
 ChEBI:39112 BOSUTINIB      0.499 2
 ChEBI:49375 DASATINIB      0.499 2
 UniProt:Q92569 PIK3R3  2 0.488 2
 UniProt:Q9P2D0 IBTK      0.463 2
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