Reactome | Cellular responses to mechanical stimuli

Cellular responses to mechanical stimuli

Stable Identifier

R-HSA-9855142

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cellular responses to mechanical stimuli

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Molecular mechanosensors are biomolecules that convert a physical force into an intracellular chemical signal (reviewed in Martino et al. 2018, Li et al. 2022). One of the most common types of mechanosensor is the mechanically gated ion channel such as PIEZO1 (reviewed in Fang et al. 2021). Other mechanosensors include integrins (reviewed in Hirata et al. 2015) and receptors such as AGTR1 and GPR68 (reviewed in Xiao et al. 2023). After activation by force, mechanosensors then activate mechanotransducers such as kinases and channels to amplify and transfer the signal to chemical processes that produce downstream effects such as changes in gene expression, cell growth, and behavior (reviewed in Martino et al. 2018).
Mechanosensors and mechanotransducers enable endothelial cells to respond to laminar and turbulent blood flow (reviewed in Davis et al. 2023, Rahaman et al. 2023, Lim and Harraz 2024), osteocytes to respond to mechanical load and fluid flow (reviewed in Qin et al. 2021, Moharrer and Boerckel 2022, Wang et al. 2023), and specialized cellular structures such as Merkel cells and Pacinian corpuscles to respond to touch (reviewed in Handler and Ginty 2021, Logan et al. 2024).

Literature References

PubMed ID	Title	Journal	Year
35300215	Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals Li, H, Zhou, WY, Xia, YY, Zhang, JX	J Inflamm Res	2022
37595342	Mechanosensitive GPCRs and ion channels in shear stress sensing Xiao, R, Liu, J, Xu, XZS	Curr Opin Cell Biol	2023
30026699	Cellular Mechanotransduction: From Tension to Function Martino, F, Perestrelo, AR, Vinarský, V, Pagliari, S, Forte, G	Front Physiol	2018
37615786	Mechanosensing and Mechanosignal Transduction in Atherosclerosis Rahaman, SG, Mahanty, M, Mukherjee, P, Dutta, B, Rahaman, SO	Curr Atheroscler Rep	2023
33422128	Structure, kinetic properties and biological function of mechanosensitive Piezo channels Fang, XZ, Zhou, T, Xu, JQ, Wang, YX, Sun, MM, He, YJ, Pan, SW, Xiong, W, Peng, ZK, Gao, XH, Shang, Y	Cell Biosci	2021
38433863	A helping hand: roles for accessory cells in the sense of touch across species Logan, DR, Hall, J, Bianchi, L	Front Cell Neurosci	2024
34312536	The mechanosensory neurons of touch and their mechanisms of activation Handler, A, Ginty, DD	Nat Rev Neurosci	2021
32550039	Molecular mechanosensors in osteocytes Qin, L, Liu, W, Cao, H, Xiao, G	Bone Res	2020
36603156	Vascular mechanotransduction Davis, MJ, Earley, S, Li, YS, Chien, S	Physiol Rev	2023
34245936	Tunnels in the rock: Dynamics of osteocyte morphogenesis Moharrer, Y, Boerckel, JD	Bone	2021
24965068	Non-channel mechanosensors working at focal adhesion-stress fiber complex Hirata, H, Tatsumi, H, Hayakawa, K, Sokabe, M	Pflugers Arch	2015
36368521	The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology Wang, J, Sun, YX, Li, J	Dev Biol	2023
37863105	Mechanosensing by Vascular Endothelium Lim, XR, Harraz, OF	Annu Rev Physiol	2024