Reactome | TASL recruits IRF5

TASL recruits IRF5

Stable Identifier

R-HSA-9860290

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endolysosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
        
        TASL recruits IRF5 (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - SLC15A4:TASL-dependent IRF5 activation (Homo sapiens)
        
        TASL recruits IRF5 (Homo sapiens)

General

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Following activation of endosomal Toll like receptors (TLR7, TLR8, and TLR9), the SLC15A4:TASL complex mediates the recruitment of interferon regulatory factor 5 (IRF5) to its pLxIS motif (Heinz LX. et al., 2020). The formation of SLC15A4:TASL complex facilities IRF5 phosphorylation and subsequent IRF5 homodimerization downstream of endosomal TLR7-9 (Heinz LX. et al., 2020; Zhang H et al., 2023; Chen X et al., 2023; Boeszoermeny A et al., 2023). Once activated, IRF5 translocates to the nucleus to induce the transcription of genes encoding type I interferons (IFNs) and pro-inflammatory cytokines.

Literature References

PubMed ID	Title	Journal	Year
32433612	TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9 Mbow, ML, Bensimon, A, Bigenzahn, JW, Sedlyarov, V, Rebsamen, M, Kapoor, U, Superti-Furga, G, Essletzbichler, P, Li, J, Heinz, LX, Pizzagalli, MD, Girardi, E, César-Razquin, A, Lee, J, Goldmann, U, Müller, AC, Scorzoni, S, Papakostas, K, Stefanovic, A, Whitehurst, CE, Kartnig, F, King, FJ	Nature	2020