Reactome | PDPK1 (PDK1) phosphorylates PKN2 on threonine-816

PDPK1 (PDK1) phosphorylates PKN2 on threonine-816

Stable Identifier

R-HSA-9860785

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PDPK1 (PDK1) phosphorylates PKN2 on threonine-816

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Activated (phosphorylated) PDPK1 (PDK1) phosphorylates PKN2 (PRK2) on threonine-816 located in the activation loop (Balendran et al. 2000, Dettori et al. 2009, Jin et al. 2021). Threonine-958 of PKN2 may also be phosphorylated (Dettori et al. 2009). A hydrophobic motif in the C-terminal region of PKN2 interacts with the kinase domain of PDPK1 (Balendran et al. 2000, Dettori et al. 2009). Laminar flow stress on endothelial cells activates PDPK1 to phosphorylate PKN2, which then phosphorylates AKT1 on threonine-308 (Jin et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
34499618	Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation Offermanns, S, Wettschureck, N, Graumann, J, Jin, YJ, Liang, G, Li, R, Chennupati, R, Iring, A, Wang, S	J Clin Invest	2021
19723632	Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) Engel, M, Dettori, R, Sonzogni, S, Piiper, A, Frödin, M, Neimanis, S, Zeuzem, S, Morrice, NA, Meyer, L, Lopez-Garcia, LA, Biondi, RM	J. Biol. Chem.	2009
10764742	A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 Deak, M, Casamayor, A, Cheung, PC, Biondi, RM, Alessi, DR, Balendran, A	J Biol Chem	2000