Reactome | Secretion of ADM (Adrenomedullin)

Secretion of ADM (Adrenomedullin)

Stable Identifier

R-HSA-9861331

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

secretory granule lumen, extracellular region

ReviewStatus

5/5

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Stimulation of the mechanosensitive cation channel PIEZO1 by laminar flow shear stress causes an influx of Ca2+ that activates secretion of Adrenomedullin (AM) by endothelial cells (Iring et al. 2019, and inferred from bovine pulmonary endothelial cells in Dschietzig et al. 2001). Shear stress also increases the steady state level of AM mRNA in endothelial cells (Chun et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
31205027	Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure Wettschureck, N, Graumann, J, Nakayama, A, Weinstein, LS, Günther, S, Künne, C, Wang, S, Offermanns, S, Dancs, PT, Sokol, AM, Jin, YJ, Chen, M, Albarrán-Juárez, J, Tonack, S, Siragusa, M, Martínez, A, Iring, A, Fleming, I	J Clin Invest	2019