Reactome | p-S26-ANXA2 [cytosol]

p-S26-ANXA2 [cytosol]

Stable Identifier

R-HSA-9865163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Annexin A2, ANXA2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q14508 WFDC2

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External Reference Information

External Reference

UniProt:P07355 ANXA2

Gene Names

ANXA2, ANX2, ANX2L4, CAL1H, LPC2D

Chain

initiator methionine:, chain:2-339

Reference Genes

BioGPS Gene:302 ANXA2

COSMIC (genes):ANXA2 ANXA2

CTD Gene:302 ANXA2

dbSNP Gene:302 ANXA2

ENSEMBL:ENSG00000182718 ANXA2

HGNC:537 ANXA2

KEGG:hsa:302 ANXA2

Monarch:302 ANXA2

NCBI Gene:302 ANXA2

OMIM:151740 ANXA2

UCSC:P07355 ANXA2

Reference Transcript

Other Identifiers

11738551_a_at

11738552_x_at

11740879_s_at

11740880_x_at

11747282_x_at

11753399_x_at

11754064_x_at

201590_PM_x_at

201590_x_at

210427_PM_x_at

210427_x_at

213503_PM_x_at

213503_x_at

302

31444_s_at

3167111

3627282

3627283

3627284

3627285

3627286

3627287

3627288

3627289

3627291

3627292

3627294

3627295

3627296

3627297

3627298

3627299

3627300

3627301

3627302

3627303

3627304

3627305

3627306

3627307

3627308

3627309

3627310

3627311

3627312

3627313

3627314

3627315

3627316

3627323

3627324

3627325

3627328

3627329

3627330

3627331

3627332

3627333

3627334

3627337

3627338

3627339

3627340

3627341

3627344

3627345

3627346

3627347

3627348

3627349

3627352

3627353

3627354

3627355

3627356

3627357

42058_at

58798_at

68395_at

71801_i_at

71803_f_at

72514_at

757_at

76043_at

769_s_at

7989335

A_23_P146644

A_32_P94798

D00017_at

D28364_at

GE61578

GE79122

GO:0001525

GO:0001533

GO:0001765

GO:0001786

GO:0001921

GO:0002020

GO:0002091

GO:0003723

GO:0004859

GO:0004867

GO:0005215

GO:0005262

GO:0005509

GO:0005515

GO:0005544

GO:0005546

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005737

GO:0005765

GO:0005768

GO:0005769

GO:0005811

GO:0005829

GO:0005886

GO:0005912

GO:0006351

GO:0006355

GO:0006900

GO:0007155

GO:0007160

GO:0008092

GO:0008289

GO:0009986

GO:0010756

GO:0012501

GO:0012506

GO:0014823

GO:0016020

GO:0016071

GO:0016323

GO:0016363

GO:0019834

GO:0030198

GO:0030199

GO:0030312

GO:0030324

GO:0030496

GO:0031012

GO:0031340

GO:0031410

GO:0031902

GO:0031982

GO:0032804

GO:0035578

GO:0035749

GO:0036035

GO:0042383

GO:0042470

GO:0042730

GO:0042789

GO:0042802

GO:0043220

GO:0043226

GO:0044090

GO:0044548

GO:0045121

GO:0045921

GO:0045944

GO:0046790

GO:0048306

GO:0048856

GO:0050767

GO:0055085

GO:0061024

GO:0062023

GO:0070062

GO:0070588

GO:0090575

GO:0098609

GO:0098631

GO:0098641

GO:0098772

GO:0098797

GO:1904019

GO:1905581

GO:1905597

GO:1905599

GO:1905602

GO:1905686

GO:1990665

GO:1990667

HMNXSV003048221

ILMN_1711899

ILMN_1755937

ILMN_2409167

PH_hs_0030492

TC09000149.hg

TC09001875.hg

TC15001505.hg

g12655074_3p_a_at

g187147_3p_x_at

Participates

as an output of

PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Homo sapiens)

as an input of

p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane (Homo sapiens)

as a component of

Other forms of this molecule

ANXA2 [azurophil granule lumen]

ANXA2 [extracellular region]

p-Y24,S26-ANXA2 [cytosol]

ANXA2 [external side of plasma membrane]

ANXA2 [cytosol]

Inferred To

Ghost homologue of p-S26-ANXA2 [cytosol] (Caenorhabditis elegans)

phospho-nxnA [cytosol] (Dictyostelium discoideum)

phospho-AnxB10 [cytosol] (Drosophila melanogaster)

phospho-anxa2a [cytosol] (Danio rerio)

Homologues of p-S26-ANXA2 [cytosol] (Dictyostelium discoideum)

phospho-Anxa2 [cytosol] (Mus musculus)

phospho-Anxa2 [cytosol] (Rattus norvegicus)

phospho-nxnB [cytosol] (Dictyostelium discoideum)

phospho-anxa2 [cytosol] (Xenopus tropicalis)

phospho-ANXA2 [cytosol] (Bos taurus)

phospho-ANXA2 [cytosol] (Canis familiaris)

phospho-ANXA2 [cytosol] (Gallus gallus)

phospho-ANXA2 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 26

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

OpenTargets

ENSG00000182718

ENSEMBL

ENSP00000453859, ENSP00000504035, ENST00000559818, ENSP00000411352, ENSP00000453694, ENSP00000452981, ENST00000332680, ENST00000558558, ENSP00000379342, ENSP00000503447, ENSP00000346032, ENST00000678061, ENST00000451270, ENSP00000387545, ENST00000677968, ENST00000396024, ENSP00000504164, ENSP00000452895, ENST00000557906, ENST00000678450, ENST00000560468, ENST00000679109, ENSP00000452858, ENST00000559956, ENSP00000503757, ENST00000421017, ENSP00000503855, ENST00000678870

HPA

ENSG00000182718-ANXA2

PRO

P07355

Pharos - Targets

P07355

GlyGen

P07355

HMDB Protein

HMDBP02277

PDB

5LQ0, 7ZVX, 4FTG, 6TWU, 7PCB, 5LPU, 7QQM, 4DRW, 7P74, 7PC8, 7P72, 7PC9, 6TWX, 7QQL, 7QQN, 5LPX, 7P73, 7PC7, 1W7B, 2HYU, 2HYV, 2HYW, 7DTO, 5N7F, 5N7G, 5N7D, 6TWQ, 5LQ2, 7ZVN, 1XJL, 7P70, 6TWY, 8AEL, 7NMI, 7PC4, 7EQ7, 7PC3, 7PC5, 7P71, 4HRH

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15363 P37			0.78	24
UniProt:Q14508 WFDC2	1	WFDC2 [extracellular region] (R-HSA-9830363)	0.736	37
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.723	10
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.695	6
UniProt:Q15599 NHRF2			0.65	6
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667)	0.622	5
UniProt:P75409 CARDS			0.619	6
UniProt:Q8NBP7 PCSK9	5	PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.61	7
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.602	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.583	4
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.573	2
UniProt:Q99IB8-PRO_0000045602			0.57	5
IntAct:EBI-6863782 NS3			0.564	2
ChEBI:28304 HEPARIN			0.564	4
UniProt:B7UM99 TIR			0.557	3
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.537	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q7DB77 TIR			0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q15811-1 ITSN1			0.524	2
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.484	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P27958-PRO_0000037575			0.463	2

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