Kinesin-13 is a dimer

Stable Identifier
R-HSA-990489
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Kinesin-13 is a dimer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Kinesin-13 proteins are homodimeric with the kinesin motor in the middle of the amino acid sequence. They induce microtubule depolymerization by disassembling tubulin subunits from the polymer end (Desai et al. 1999).
Literature References
PubMed ID Title Journal Year
7822426 Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis

Mitchison, TJ, Wordeman, L

J Cell Biol 1995
17538014 The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells

Compton, DA, Bakhoum, SF, Manning, AL, Wagenbach, M, Wordeman, L, Ganem, NJ

Mol Biol Cell 2007
Participants
Input
Output
Participates
as an event of
Orthologous Events
Kinesin-13 is a dimer (Bos taurus)
Kinesin-13 is a dimer (Caenorhabditis elegans)
Kinesin-13 is a dimer (Canis familiaris)
Kinesin-13 is a dimer (Drosophila melanogaster)
Kinesin-13 is a dimer (Gallus gallus)
Kinesin-13 is a dimer (Mus musculus)
Kinesin-13 is a dimer (Rattus norvegicus)
Kinesin-13 is a dimer (Sus scrofa)
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-03)
Cite Us!