Interaction of PCBP2 with MAVS

Stable Identifier
R-HSA-990528
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Interaction of PCBP2 with MAVS
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Poly(rC) binding protein 2 (PCB2), is one of the negative regulators of RIG-I (DDX58) and IFIH1 (MDA5) signaling pathways. It interacts with MAVS (IPS-1) and mediates its ubiquitin/proteasomal degradation by recruiting E3 ligase AIP4 (ITCH).
Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X

Nat Immunol 2009
Participants
Input
Output
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as an event of
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-11-03)
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