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About
What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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COVID-19 Disease Pathways
Docs
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19S RP lid particle 3 [cytosol]
Stable Identifier
R-HSA-9908004
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
PSMD3:PSMD6:SEM1, Rpn3:Rpn7:Sem1, 19S RP LP3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Proteasome mediated degradation of COP1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Homo sapiens)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Proteasome mediated degradation of Cyclin D1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Function (Homo sapiens)
Degradation of CDH1 (Homo sapiens)
Proteasome-dependent degradation of ubiquitinated CDH1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Circadian clock (Homo sapiens)
Degradation of CRY and PER proteins (Homo sapiens)
Proteolysis of K48polyUb-K,p-S-PER1,2,3 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
processing defective Hh variants are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Proteosome-mediated degradation of APOBEC3G (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Degradation of ubiquitinated CD4 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of soluble exogenous antigens (endosomes) (Homo sapiens)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Proteasomal cleavage of substrate (26S proteasome catalyst) (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Proteasomal cleavage of substrate (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
26Sproteasome degrades K48polyUb-NIK (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
26S proteosome degrades ODC holoenzyme complex (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1:mRNA complex is destroyed (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1 binds 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
ADRM1:26S proteaseome binds USP14 (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ADRM1:26S proteasome:USP14 [cytosol] (Homo sapiens)
ADRM1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Neddylation (Homo sapiens)
26S proteasome degrades HIFalpha (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
26S proteasome degrades Ub-NFE2L2 (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the 19S regulatory particle lid (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Formation of the 19S regulatory particle precursor (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
19S RP precursor [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Formation of the 26S proteasome (Homo sapiens)
19S RP precursor [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Formation of the complex of PSMD3, PSMD6, and SEM1 (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Formation of the lid particle 2 (LP2) (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Formation of the spermatoproteasome (Homo sapiens)
19S RP precursor [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Spermatoproteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Proteasome degrades polyubiquitinated PTEN (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
NF1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
ub-GLI is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
PRICKLE1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Degradation of DVL (Homo sapiens)
Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Ubiquitinated DVL1 is degraded by the proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)
26S proteasome [cytosol] (Homo sapiens)
19S regulatory particle [cytosol] (Homo sapiens)
19S RP lid [cytosol] (Homo sapiens)
19S RP lid particle 2 [cytosol] (Homo sapiens)
19S RP lid particle 3 [cytosol] (Homo sapiens)
Participants
components
PSMD3 [cytosol]
(Homo sapiens)
PSMD6 [cytosol]
(Homo sapiens)
SEM1 [cytosol]
(Homo sapiens)
Participates
as an output of
Formation of the complex of PSMD3, PSMD6, and SEM1 (Homo sapiens)
as an input of
Formation of the lid particle 2 (LP2) (Homo sapiens)
as a component of
19S RP lid particle 2 [cytosol] (Homo sapiens)
Inferred To
19S RP lid particle 3 [cytosol]
(Bos taurus)
19S RP lid particle 3 [cytosol]
(Caenorhabditis elegans)
19S RP lid particle 3 [cytosol]
(Canis familiaris)
19S RP lid particle 3 [cytosol]
(Danio rerio)
19S RP lid particle 3 [cytosol]
(Dictyostelium discoideum)
19S RP lid particle 3 [cytosol]
(Drosophila melanogaster)
19S RP lid particle 3 [cytosol]
(Gallus gallus)
19S RP lid particle 3 [cytosol]
(Mus musculus)
19S RP lid particle 3 [cytosol]
(Plasmodium falciparum)
19S RP lid particle 3 [cytosol]
(Rattus norvegicus)
19S RP lid particle 3 [cytosol]
(Saccharomyces cerevisiae)
19S RP lid particle 3 [cytosol]
(Schizosaccharomyces pombe)
19S RP lid particle 3 [cytosol]
(Sus scrofa)
19S RP lid particle 3 [cytosol]
(Xenopus tropicalis)
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