RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL)

Stable Identifier
R-HSA-9911580
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Synonyms
ARNTL gene produces ARNTL
ReviewStatus
5/5
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RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL)
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RORA, RORB, or RORC bind ROR responsive elements (RREs, ROREs) in the BMAL1 promoter and activate transcription of BMAL1 (inferred from mouse homologs). RORA and presumably RORB and RORC recruit coactivators p300 (EP300), PGC-1alpha (PPARGC1A), and NRIP1 to positively regulate transcription (Poliandri et al. 2011, and inferred from mouse homologs).
The heme receptor NR1D1 (REV-ERBA) competes with the ROR proteins for binding to the same RREs (inferred from mouse homologs). NR1D1 recruits the corepressors NCoR and HDAC3 to repress transcription of BMAL1 (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
21628546 Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

Poliandri, AH, Gamsby, JJ, Christian, M, Spinella, MJ, Loros, JJ, Dunlap, JC, Parker, MG

J. Biol. Rhythms 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
SIRT1 [nucleoplasm] (Homo sapiens)
Regulator
RORA,B,C:Coactivator:BMAL1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RORA,B,C [nucleoplasm]
Inferred From
Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl) (Mus musculus)
Authored
May, B  (2024-05-28)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-06-01)
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