SLC35D2 exchanges UDP-GlcA for UMP

Stable Identifier
R-HSA-9912889
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-glucuronate(out) + UMP(in)
ReviewStatus
5/5
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SLC35D2 exchanges UDP-GlcA for UMP
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Nucleotide sugar transporter SLC35D2 is inferred to mediate the exchange of UDP-GlcA and UMP across the Golgi membrane, based on the localization of SLC35D2 protein to this membrane (Ishida et al. 2005) and the close structural relationship between SLC35D2 and SLC35D1, which mediates UDP-GlcA transport across the ER membrane (Muraoka et al. 2001).
Literature References
PubMed ID Title Journal Year
15607426 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family

Ishida, N, Miyatake, S, Sanai, Y, Kawakita, M, Aoki, K, Kuba, T

Genomics 2005
17599910 Variety of nucleotide sugar transporters with respect to the interaction with nucleoside mono- and diphosphates

Ishida, N, Kawakita, M, Muraoka, M, Miki, T, Hara, T

J Biol Chem 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

UDP-glucuronate transmembrane transporter activity of SLC35D2 [Golgi membrane]

Physical Entity
SLC35D2 [Golgi membrane] (Homo sapiens)
Activity
UDP-glucuronate transmembrane transporter activity (GO:0005461)
Inferred From
SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2024-06-10)
Reviewed
Hill, DP  (2024-07-19)
Created
D'Eustachio, P  (2024-06-10)
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