Activation of GABAB receptors

Stable Identifier
R-HSA-991365
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Pathway
Species
Homo sapiens
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GABA B receptors are metabotropic receptors that are functionally linked to C type G protein coupled receptors.? GABA B receptors are activated upon ligand binding. The GABA B1 subunit binds ligand and GABA B2 subunit modulates the activity of adenylate cyclase via the intracellular loop.? GABA B receptors show inhibitory activity via Galpha/G0 subunits via the inhibition of adenylate cyclase or via the activity of Gbeta/gamma subunits that mediate the inhibition of voltage gated Ca2+ channels.

Literature References
PubMed ID Title Journal Year
20655481 GABAB receptor coupling to G-proteins and ion channels

Padgett, CL, Slesinger, PA

Adv Pharmacol 2010
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