CLOCK acetylates BMAL1 on lysine-538

Stable Identifier
R-HSA-9920716
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CLOCK acetylates BMAL1 on lysine-538
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CLOCK in the BMAL1:CLOCK heterodimer acetylates lysine-538 of BMAL1 (inferred from mouse homologs). The acetylation reaction occurs in the evening at the time when transactivation by BMAL1:CLOCK declines (inferred from mouse homologs). The acetylation is required for efficient interaction with the CRY:PER:kinase complex that represses BMAL1:CLOCK activity (inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein-lysine-acetyltransferase activity of p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm]

Physical Entity
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm] (Homo sapiens)
Activity
protein-lysine-acetyltransferase activity (GO:0061733)
Inferred From
Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2) (Mus musculus)
Authored
May, B  (2024-08-15)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-03)
Cite Us!