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p-T451,T461-CLOCK is phosphorylated on serines-440,441,446
Stable Identifier
R-HSA-9920724
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Circadian clock (Homo sapiens)
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
An unidentified kinase or kinases phosphorylates three serine residues (S440, S441, S446) of CLOCK (inferred from the mouse homolog).
Participants
Input
x 3
ATP [nucleoplasm]
p-S90-BMAL1:p-T451,T461-CLOCK:target gene [nucleoplasm]
(Homo sapiens)
Output
x 3
ADP [nucleoplasm]
p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:target gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters (Homo sapiens)
Inferred From
p-T451,T461-Clock is phosphorylated on serines-440,441,446 (Mus musculus)
Authored
May, B (2024-08-15)
Reviewed
Sancar, A (2025-02-14)
Albrecht, U (2025-02-18)
Created
May, B (2024-09-03)
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