Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Cryptochrome-1 (CRY1)

Stable Identifier
R-HSA-9922989
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Cryptochrome-1 (CRY1)
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Phosphorylated BMAL1:CLOCK bound to an E-box in the CRY1 promoter recruits the histone acetyltransferase CREBBP and the histone methyltransferase KMT2A and enhance transcription of CRY1 (Nakamura et al. 2008, and inferred from mouse homologs). CRY1 is expressed in a circadian rhythm in all tissues tested (inferred from mouse homologs). NPAS2 acts redundantly with CLOCK to form heterodimers with BMAL1 and regulate CRY1 expression (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
18317514 Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems

Nakamura, K, Inoue, I, Takahashi, S, Komoda, T, Katayama, S

PPAR Res 2008
Participants
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Output
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as an event of
This event is regulated
Positively by
Regulator
p-S90-BMAL1:p-T451,T461-CLOCK,p-S-NPAS2:KMT2A:CRY1 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 [nucleoplasm]
Inferred From
Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry1 (Mus musculus)
Authored
May, B  (2024-09-21)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-29)
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