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MFN2 [mitochondrial outer membrane]
Stable Identifier
R-HSA-992714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-2, MFN2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9NX47%20MARH5
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95140 MFN2
Gene Names
MFN2, CPRP1, KIAA0214
Chain
chain:1-757
Reference Genes
BioGPS Gene:9927 MFN2
COSMIC (genes):MFN2 MFN2
CTD Gene:9927 MFN2
dbSNP Gene:9927 MFN2
ENSEMBL:ENSG00000116688 MFN2
ENSEMBL_homo_sapiens_GENE:ENSG00000116688.18 MFN2
HGNC:16877 MFN2
KEGG Gene (Homo sapiens):9927 MFN2
Monarch:9927 MFN2
NCBI Gene:9927 MFN2
OMIM:608507 MFN2
UCSC:O95140 MFN2
Reference Transcript
RefSeq:XM_005263547.3 MFN2
RefSeq:XM_005263545.3 MFN2
RefSeq:NM_014874.3 MFN2
RefSeq:XM_005263548.3 MFN2
RefSeq:NM_001127660.1 MFN2
RefSeq:XM_005263543.3 MFN2
Other Identifiers
11739020_a_at
11741010_a_at
11748427_a_at
16659171
201155_PM_s_at
201155_s_at
216205_PM_s_at
216205_s_at
2320620
2320622
2320623
2320624
2320625
2320626
2320630
2320632
2320633
2320635
2320636
2320638
2320639
2320641
2320643
2320644
2320645
2320646
2320647
2320648
2320649
2320650
2320651
2320652
2320653
2320654
2320655
2320656
34369_at
7897824
9927
A_14_P132643
A_23_P126135
A_33_P3320277
GE57383
GO:0000166
GO:0001825
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0006626
GO:0006886
GO:0006914
GO:0006915
GO:0006986
GO:0007005
GO:0007006
GO:0008053
GO:0012501
GO:0015630
GO:0016020
GO:0016787
GO:0023052
GO:0031625
GO:0034497
GO:0043226
GO:0046580
GO:0048593
GO:0048662
GO:0048856
GO:0051646
GO:0061024
GO:0061734
GO:0120162
GO:1904707
GO:1905461
HMNXSV003052093
Hs.3363.2.S1_3p_a_at
ILMN_1651385
PH_hs_0024267
TC01000152.hg
g7662003_3p_a_at
Participates
as a member of
RHOT2 effectors [cytosol] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
as an input of
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
Other forms of this molecule
K48polyUb-MFN2 [mitochondrial outer membrane]
Inferred To
Homologues of MFN2 [mitochondrial outer membrane]
(Drosophila melanogaster)
MFN2 [mitochondrial outer membrane]
(Bos taurus)
MFN2 [mitochondrial outer membrane]
(Caenorhabditis elegans)
MFN2 [mitochondrial outer membrane]
(Canis familiaris)
MFN2 [mitochondrial outer membrane]
(Drosophila melanogaster)
MFN2 [mitochondrial outer membrane]
(Gallus gallus)
MFN2 [mitochondrial outer membrane]
(Mus musculus)
MFN2 [mitochondrial outer membrane]
(Plasmodium falciparum)
MFN2 [mitochondrial outer membrane]
(Rattus norvegicus)
MFN2 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
MFN2 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
MFN2 [mitochondrial outer membrane]
(Sus scrofa)
mfn2 [mitochondrial outer membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005263602.1
,
XP_005263605.1
,
NP_055689.1
,
NP_001121132.1
,
XP_005263604.1
,
XP_005263600.1
Guide to Pharmacology - Targets
3131
OpenTargets
ENSG00000116688
HPA
ENSG00000116688-MFN2
GeneCards
O95140
Ensembl
ENSP00000501716
,
ENSG00000116688
,
ENSP00000416338
,
ENST00000674548
,
ENST00000444836
,
ENSP00000501646
,
ENSP00000502362
,
ENST00000675231
,
ENST00000675919
,
ENST00000674817
,
ENST00000675053
,
ENSP00000502151
,
ENSP00000502185
,
ENST00000675113
,
ENST00000674910
,
ENST00000235329
,
ENSP00000502623
,
ENSP00000502404
,
ENSP00000501776
,
ENST00000676293
,
ENSP00000235329
PRO
O95140
Pharos - Targets
O95140
Orphanet
16394
HMDB Protein
HMDBP08482
PDB
6JFL
,
6JFK
,
6JFM
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PARK2
3
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
PRKN [cytosol]
(R-HSA-201579)
0.576
4
UniProt:Q9NX47 MARH5
0.564
2
UniProt:Q8IWA4 MFN1
2
K48polyUb-MFN1 [mitochondrial outer membrane]
(R-HSA-5205679)
MFN1 [mitochondrial outer membrane]
(R-HSA-992745)
0.564
2
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
3
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