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p-S6-SPOP [cytosol]
Stable Identifier
R-HSA-9929374
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Ser6-SPOP
Locations in the PathwayBrowser for interactor UniProt:P04626 ERBB2
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Regulation of PD-L1(CD274) expression (Homo sapiens)
Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
SPOP-mediated proteasomal degradation of PD-L1(CD274) (Homo sapiens)
CDK4:CCND1 phosphorylates SPOP (Homo sapiens)
p-S6-SPOP [cytosol] (Homo sapiens)
p-S6-SPOP binds YWHAG (Homo sapiens)
p-S6-SPOP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43791 SPOP
Gene Names
SPOP
Chain
chain:1-374
Reference Genes
BioGPS Gene:8405 SPOP
COSMIC (genes):SPOP SPOP
CTD Gene:8405 SPOP
dbSNP Gene:8405 SPOP
ENSEMBL:ENSG00000121067 SPOP
HGNC:11254 SPOP
KEGG:hsa:8405 SPOP
Monarch:8405 SPOP
NCBI Gene:8405 SPOP
OMIM:602650 SPOP
UCSC:O43791 SPOP
Reference Transcript
RefSeq:NM_001370730.1 SPOP
RefSeq:NM_001007227.1 SPOP
RefSeq:NM_001370731.1 SPOP
RefSeq:XM_054317516.1 SPOP
RefSeq:NM_003563.3 SPOP
RefSeq:NM_001007226.1 SPOP
RefSeq:NM_001007230.1 SPOP
RefSeq:NM_001370732.1 SPOP
RefSeq:XM_005257723.4 SPOP
RefSeq:XM_005257724.4 SPOP
RefSeq:XM_024450995.2 SPOP
RefSeq:XM_017025204.1 SPOP
RefSeq:NM_001007228.2 SPOP
RefSeq:NM_001007229.1 SPOP
Other Identifiers
11730177_a_at
11730178_s_at
11730179_a_at
11743913_s_at
16846448
204640_PM_s_at
204640_s_at
208927_PM_at
208927_at
238923_PM_at
238923_at
3761902
3761904
3761906
3761907
3761908
3761909
3761910
3761911
3761912
3761913
3761916
3761917
3761918
3761919
3761920
3761921
3761922
3761923
3761926
3761927
3761928
3761929
3761930
3761931
3761935
3761936
3761938
3761943
3761944
3761947
3761948
39423_f_at
44052_at
8016562
80786_at
8405
A_23_P107257
A_24_P270890
GE55133
GO:0000209
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0016567
GO:0016607
GO:0030162
GO:0030163
GO:0031463
GO:0031625
GO:0042802
GO:0043161
GO:0098772
GO:0140678
HMNXSV003032558
Hs.129951.1.S2_3p_at
Hs.151316.0.A1_3p_at
ILMN_1795404
ILMN_2397024
PH_hs_0007623
TC17001670.hg
g4507182_3p_a_at
Participates
as a component of
p-S6-SPOP:YWHAG [cytosol] (Homo sapiens)
as an input of
p-S6-SPOP binds YWHAG (Homo sapiens)
as an output of
CDK4:CCND1 phosphorylates SPOP (Homo sapiens)
Other forms of this molecule
SPOP [cytosol]
SPOP [nucleoplasm]
Inferred To
rdx [cytosol]
(Drosophila melanogaster)
spop [cytosol]
(Danio rerio)
spop [cytosol]
(Xenopus tropicalis)
bath-44 [cytosol]
(Caenorhabditis elegans)
SPOP [cytosol]
(Bos taurus)
SPOP [cytosol]
(Canis familiaris)
SPOP [cytosol]
(Gallus gallus)
SPOP [cytosol]
(Sus scrofa)
Dmel\CG11275 [cytosol]
(Drosophila melanogaster)
Spop [cytosol]
(Mus musculus)
Spop [cytosol]
(Rattus norvegicus)
Q54WU7 [cytosol]
(Dictyostelium discoideum)
Homologues of p-S6-SPOP [cytosol]
(Caenorhabditis elegans)
Homologues of p-S6-SPOP [cytosol]
(Drosophila melanogaster)
bath-40 [cytosol]
(Caenorhabditis elegans)
bath-41 [cytosol]
(Caenorhabditis elegans)
spop-1 [cytosol]
(Caenorhabditis elegans)
bath-42 [cytosol]
(Caenorhabditis elegans)
Dmel\CG7058 [cytosol]
(Drosophila melanogaster)
mel-26 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001007228.1
,
NP_001357660.1
,
NP_001007229.1
,
NP_001357661.1
,
NP_001007231.1
,
NP_001357659.1
,
NP_001007227.1
,
XP_016880693.1
,
XP_024306763.1
,
XP_054173491.1
,
NP_003554.1
,
NP_001007230.1
,
XP_005257781.1
,
XP_005257780.1
OpenTargets
ENSG00000121067
ENSEMBL
ENSG00000121067
,
ENST00000347630
,
ENST00000503676
,
ENSP00000240327
,
ENSP00000426986
,
ENST00000509079
,
ENST00000665825
,
ENSP00000420908
,
ENSP00000425905
,
ENSP00000499562
,
ENST00000504102
,
ENSP00000424119
,
ENSP00000377001
,
ENST00000393328
,
ENST00000514121
GeneCards
SPOP
HPA
ENSG00000121067-SPOP
PRO
O43791
Pharos - Targets
O43791
PDB
4HS2
,
6I5P
,
3HQM
,
3HQH
,
3HSV
,
3HQI
,
6I41
,
4EOZ
,
6F8G
,
7LIQ
,
6F8F
,
7D3D
,
7LIP
,
6I68
,
6I7A
,
4J8Z
,
3HTM
,
3IVV
,
3HU6
,
3HQL
,
7KLZ
,
3IVB
,
4O1V
,
3IVQ
,
8DWV
,
8DWT
,
8DWS
,
2CR2
,
8DWU
,
7LIN
,
7LIO
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.89
13
UniProt:Q99836 MYD88
8
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.875
12
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.757
9
UniProt:Q9Y6Q9 NCOA3
2
NCOA3 [nucleoplasm]
(R-HSA-442488)
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
0.736
11
UniProt:O43791 SPOP
3
SPOP [cytosol]
(R-HSA-9929375)
p-S6-SPOP [cytosol]
(R-HSA-9929374)
SPOP [nucleoplasm]
(R-HSA-5635035)
0.694
9
UniProt:P60484 PTEN
20
K48polyUb-PTEN [cytosol]
(R-HSA-8874327)
PolyUb-PTEN [nucleoplasm]
(R-HSA-6782515)
PTEN H93R [cytosol]
(R-HSA-2318524)
PTEN C124R [cytosol]
(R-HSA-2317439)
PTEN H93Y [cytosol]
(R-HSA-2318520)
PTEN R130G [cytosol]
(R-HSA-2317339)
PTEN H93D [cytosol]
(R-HSA-2318550)
PTEN R130L [cytosol]
(R-HSA-2317430)
PTEN H93A [cytosol]
(R-HSA-2318544)
PTEN G129E [cytosol]
(R-HSA-2318509)
PTEN S170N [cytosol]
(R-HSA-2318408)
PTEN R173P [cytosol]
(R-HSA-2317480)
PTEN R130Q [cytosol]
(R-HSA-2317416)
PTEN H93Q [cytosol]
(R-HSA-2318565)
PTEN G129R [cytosol]
(R-HSA-2318501)
PTEN H123Y [cytosol]
(R-HSA-2318469)
PTEN S170R [cytosol]
(R-HSA-2318437)
PTEN R173C [cytosol]
(R-HSA-2317478)
PTEN R173H [cytosol]
(R-HSA-2317473)
PTEN C124S [cytosol]
(R-HSA-2317379)
0.611
4
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.596
5
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.596
7
UniProt:Q76L83 ASXL2
1
ASXL2 [nucleoplasm]
(R-HSA-5689629)
0.596
6
UniProt:Q8N680 ZBTB2
0.596
6
UniProt:Q6IQ16 SPOPL
1
SPOPL [nucleoplasm]
(R-HSA-5635036)
0.59
3
UniProt:P53278 YG3A
0.556
3
UniProt:P40959 MVP1
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:P53202
1
CUL3 [cytosol]
(R-SCE-8952516)
0.556
3
UniProt:Q08273
3
HRT1 [cytosol]
(R-SCE-8863132)
HRT1 [cytosol]
(R-SCE-180582)
HRT1 [nucleoplasm]
(R-SCE-1234142)
0.556
3
UniProt:Q05164 HPF1
0.556
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.553
6
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.553
4
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.553
6
UniProt:P28702 RXRB
1
RXRB [nucleoplasm]
(R-HSA-446163)
0.553
2
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.553
6
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.553
6
UniProt:P15976 GATA1
1
GATA1 [nucleoplasm]
(R-HSA-996772)
0.553
6
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.544
5
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
2
UniProt:Q9BQB4 SOST
1
SOST [extracellular region]
(R-HSA-3769322)
0.527
2
UniProt:Q77UU1 Q77UU1
0.488
2
UniProt:P04015 VE2
0.488
2
UniProt:P36778 VE2
0.488
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.471
5
UniProt:P16871 IL7R
3
p-Y449-IL7R [plasma membrane]
(R-HSA-1295531)
IL7R [plasma membrane]
(R-HSA-449945)
IL7R [clathrin-coated endocytic vesicle membrane]
(R-HSA-9028500)
0.471
5
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA [cytosol]
(R-HSA-74787)
PIK3CA R38C [cytosol]
(R-HSA-1500691)
PIK3CA R38G [cytosol]
(R-HSA-2395950)
PIK3CA R38S [cytosol]
(R-HSA-2395947)
PIK3CA R38H [cytosol]
(R-HSA-1500718)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
0.471
4
UniProt:O60885 BRD4
1
BRD4 [nucleoplasm]
(R-HSA-9680425)
0.471
5
UniProt:Q15329 E2F5
1
E2F5 [nucleoplasm]
(R-HSA-68669)
0.471
5
UniProt:P50549 ETV1
0.471
5
UniProt:Q06455 MTG8
0.471
5
UniProt:O00750 PIK3C2B
1
PIK3C2B [cytosol]
(R-HSA-1604619)
0.471
5
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.454
5
UniProt:P30530 AXL
3
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
AXL [endosome membrane]
(R-HSA-9949473)
0.454
5
UniProt:Q14832 GRM3
1
GRM3 [plasma membrane]
(R-HSA-420509)
0.454
5
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