Reactome | p-Y1034-JAK1 [endoplasmic reticulum lumen]

p-Y1034-JAK1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-9931304

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

p(Y1034)-JAK1, Tyrosine-protein kinase JAK1, JAK1_HUMAN, Janus kinase 1

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Locations in the PathwayBrowser for interactor UniProt:P15260 IFNGR1

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        IL6-activated JAK1 phosphorylates CD274 (Homo sapiens)
        
        p-Y1034-JAK1 [endoplasmic reticulum lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23458 JAK1

Gene Names

JAK1, JAK1A, JAK1B

Chain

chain:1-1154

Reference Genes

BioGPS Gene:3716 JAK1

COSMIC (genes):JAK1 JAK1

CTD Gene:3716 JAK1

dbSNP Gene:3716 JAK1

ENSEMBL:ENSG00000162434 JAK1

HGNC:6190 JAK1

KEGG:hsa:3716 JAK1

Monarch:3716 JAK1

NCBI Gene:3716 JAK1

OMIM:147795 JAK1

UCSC:P23458 JAK1

Reference Transcript

Other Identifiers

11717685_at

11717686_a_at

11717687_a_at

1457_at

1552610_PM_a_at

1552610_a_at

1552611_PM_a_at

1552611_a_at

16688164

16688214

17120092

17120096

201648_PM_at

201648_at

239695_PM_at

239695_at

2416521

2416523

2416524

2416525

2416526

2416528

2416529

2416530

2416531

2416532

2416534

2416535

2416536

2416537

2416538

2416539

2416540

2416541

2416542

2416544

2416545

2416549

2416550

2416551

2416552

2416553

2416556

2416558

2416559

2416560

2416561

2416562

2416563

2416564

2416566

2416568

2416569

2416570

2416582

2416593

2416594

2416595

2416602

2416607

2416609

2416611

2416692

2416709

2416711

34877_at

3716

41594_at

7916747

82666_at

A_21_P0001139

A_21_P0010621

A_21_P0010623

A_21_P0010761

A_23_P97005

A_24_P410678

A_33_P3784283

GE58033

GE725934

GE746360

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006355

GO:0006357

GO:0006468

GO:0007259

GO:0009898

GO:0012505

GO:0016020

GO:0016301

GO:0016740

GO:0019221

GO:0019903

GO:0022407

GO:0030154

GO:0030155

GO:0031234

GO:0031625

GO:0031730

GO:0034112

GO:0035556

GO:0035723

GO:0035771

GO:0038110

GO:0038111

GO:0038113

GO:0038154

GO:0038196

GO:0043235

GO:0046677

GO:0046872

GO:0051239

GO:0060333

GO:0060337

GO:0060397

GO:0070102

GO:0072540

GO:0098586

GO:0098761

GO:0140096

GO:0140105

GO:0150105

GO:1900182

GO:1903672

HMNXSV003011048

HMNXSV003017459

HMNXSV003020647

HMNXSV003057545

Hs.144848.0.A1_3p_at

Hs.50651.0.S2_3p_at

Hs2.398570.1.S1_3p_at

Hs2.50651.1.S1_3p_s_at

Hs2.50651.1.S2_3p_s_at

ILMN_1793384

M64174_at

PH_hs_0025462

PH_hs_0039571

TC01002741.hg

TC01002742.hg

TC01002747.hg

TC01005539.hg

TC01005542.hg

p232

p25648

p28938

Other forms of this molecule

p-Y-JAK1 [cytosol]

JAK1 [cytosol]

p-Y1034-JAK1 [cytosol]

p-JAK1 [cytosol]

JAK1 [endosome]

p-Y1034,Y1035-JAK1 [cytosol]

Inferred To

phospho-Jak1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-p-Y1034-JAK1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-JAK1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-JAK1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-JAK1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-JAK1 [endoplasmic reticulum lumen] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1034

Coordinate

1034

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001308783.1, NP_001308784.1, NP_002218.2, XP_047275630.1, XP_054192401.1, XP_047275631.1, NP_001308781.1, NP_001308782.1, NP_001307852.1, NP_001308785.1

ZINC - World Drugs

JAK1_HUMAN

Guide to Pharmacology - Targets

2047

OpenTargets

ENSG00000162434

ENSEMBL

ENST00000671929, ENST00000342505, ENSP00000514291, ENST00000699262, ENSG00000162434, ENSP00000500841, ENSP00000514243, ENSP00000500745, ENST00000672751, ENST00000699312, ENST00000672434, ENST00000672179, ENST00000672247, ENSP00000499900, ENSP00000499884, ENST00000671954, ENSP00000500485, ENSP00000343204, ENSP00000500296

ZINC - FDA approved

JAK1_HUMAN

ZINC - Substances

JAK1_HUMAN

ZINC - Biogenic

JAK1_HUMAN

ZINC target

P23458

PRO

P23458

PDB

4E4N, 4E5W, 4L01, 6GGH, 4I5C, 6HZU, 5E1E, 8EXJ, 5WO4, 6N7A, 6N7D, 6BBU, 8S85, 4FK6, 6TPE, 6AAH, 6RSD, 6N78, 6RSE, 4IVB, 4K6Z, 5IXI, 6W8L, 6SM8, 3EYG, 4L00, 6C7Y, 6DBN, 6ELR, 4K77, 4EHZ, 4IVD, 4GS0, 4E4L, 6N7B, 5IXD, 5KHW, 6N7C, 6TPF, 4EI4, 5KHX, 5HX8, 6SMB, 6RSC, 6N77, 6N79, 4IVC, 3EYH, 6RSH, 5L04, 6RSB

ZINC - Investigational

JAK1_HUMAN

IntEnz

2.7.10.2

GeneCards

JAK1

HPA

ENSG00000162434-JAK1

Pharos - Targets

P23458

ZINC - Predictions - Purchasable

JAK1_HUMAN

HMDB Protein

HMDBP01309

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842)	0.757	6
UniProt:P48551 IFNAR2			0.591	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.564	2
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.564	2
UniProt:P40189-1 IL6ST	1	p-5Y-IL6ST-1 [plasma membrane] (R-HSA-1112580)	0.556	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.547	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:P24394 IL4R	2	p-Y-IL4R [plasma membrane] (R-HSA-6786087) IL4R [plasma membrane] (R-HSA-449670)	0.527	2
UniProt:P04201 MAS1	1	MAS1 [plasma membrane] (R-HSA-9944591)	0.527	2
UniProt:Q8IU57 IFNLR1	2	IFNLR1 [plasma membrane] (R-HSA-448592) p-Y343-Y517-IFNLR1 [plasma membrane] (R-HSA-8987118)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.527	3
UniProt:Q9UQV4 LAMP3			0.527	2
UniProt:P15260 IFNGR1	2	IFNGR1 [plasma membrane] (R-HSA-629623) p-Y457-IFNGR1 [plasma membrane] (R-HSA-873798)	0.527	2
UniProt:P43657 LPAR6	1	LPAR6 [plasma membrane] (R-HSA-417913)	0.527	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	3
UniProt:P80370 DLK1	1	DLK1 [plasma membrane] (R-HSA-1604447)	0.527	2
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.502	2
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.471	5
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2
UniProt:O60674 JAK2	8	JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [endosome lumen] (R-HSA-2002372) JAK2 V617F [nucleoplasm] (R-HSA-5211269) p-Y813-JAK2 [cytosol] (R-HSA-997248) p-JAK2 [cytosol] (R-HSA-210621) p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327)	0.463	4

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