Reactome | PKM [nucleoplasm]

PKM [nucleoplasm]

Stable Identifier

R-HSA-9931500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Chain

initiator methionine:1, chain:2-531

Reference Genes

BioGPS Gene:5315 PKM

COSMIC (genes):PKM PKM

CTD Gene:5315 PKM

dbSNP Gene:5315 PKM

ENSEMBL:ENSG00000067225 PKM

HGNC:9021 PKM

KEGG:hsa:5315 PKM

Monarch:5315 PKM

NCBI Gene:5315 PKM

OMIM:179050 PKM

UCSC:P14618 PKM

Reference Transcript

Participates

as an input of

PKM and TGIF2 bind CDH1 gene promoter (Homo sapiens)

as a component of

PKM:TGIF2:CDH1 gene [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PKM [secretory granule lumen]

PKM [extracellular region]

PKM [ficolin-1-rich granule lumen]

Inferred To

Pkml1 [nucleoplasm] (Rattus norvegicus)

Pykl5 [nucleoplasm] (Drosophila melanogaster)

PKM [nucleoplasm] (Plasmodium falciparum)

PKM [nucleoplasm] (Sus scrofa)

pkma [nucleoplasm] (Danio rerio)

Pyk [nucleoplasm] (Drosophila melanogaster)

pyk-2 [nucleoplasm] (Caenorhabditis elegans)

Pkm [nucleoplasm] (Mus musculus)

Pykl1 [nucleoplasm] (Drosophila melanogaster)

pyk1 [nucleoplasm] (Schizosaccharomyces pombe)

pyk-1 [nucleoplasm] (Caenorhabditis elegans)

pkm [nucleoplasm] (Xenopus tropicalis)

Homologues of PKM [nucleoplasm] (Caenorhabditis elegans)

Homologues of PKM [nucleoplasm] (Drosophila melanogaster)

Homologues of PKM [nucleoplasm] (Plasmodium falciparum)

Homologues of PKM [nucleoplasm] (Saccharomyces cerevisiae)

PKLR [nucleoplasm] (Gallus gallus)

PYK2 [nucleoplasm] (Saccharomyces cerevisiae)

CDC19 [nucleoplasm] (Saccharomyces cerevisiae)

Pykl2 [nucleoplasm] (Drosophila melanogaster)

PKM2 [nucleoplasm] (Bos taurus)

Pykl3 [nucleoplasm] (Drosophila melanogaster)

pyk [nucleoplasm] (Dictyostelium discoideum)

Pykl4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_872271.1, NP_001193726.1, NP_872270.1, NP_001193725.1, NP_001303247.1, NP_001193728.1, XP_005254502.1, NP_001193727.1, XP_016877802.1, XP_047288622.1, NP_002645.3

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ENSEMBL

ENSG00000067225, ENSP00000334983, ENSP00000456970, ENST00000568459, ENST00000319622, ENST00000335181, ENSP00000320171

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

GlyGen

P14618

PDB

7L21, 3BJF, 3GR4, 6NUB, 5X0I, 1ZJH, 6TTF, 3G2G, 6GG4, 8G2E, 4QG6, 8HMU, 4FXF, 6TTI, 6NU1, 6GG3, 4G1N, 6V75, 4B2D, 4WJ8, 3SRH, 6WP6, 3SRF, 4QG9, 8HMR, 8X4R, 4JPG, 6WP4, 4RPP, 3GQY, 3U2Z, 3BJT, 8HGF, 5X1V, 5X1W, 6NU5, 6GG5, 6B6U, 4QGC, 6TTH, 3SRD, 6TTQ, 4YJ5, 6V76, 6JFB, 6GG6, 1T5A, 6WP5, 3ME3, 4FXJ, 4QG8, 8HMS, 8HMQ, 3H6O, 6V74, 6WP3

ZINC - Metabolites

KPYM_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000067225-PKM

GeneCards

PKM

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:P03129 VE7			0.646	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	20
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q96IK1-2 Q96IK12			0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9WMX2 POLG			0.556	4
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P04020 VE7			0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.524	4
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.524	3
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.519	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3

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