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YTHDC2 [nucleoplasm]
Stable Identifier
R-HSA-9935827
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="16"3'-5' RNA helicase YTHDC2 ecNumber evidence="11"3.6.4.13, YTDC2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nuclear RNA decay (Homo sapiens)
MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
YTHDC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H6S0 YTHDC2
Gene Names
YTHDC2
Chain
chain:1-1430
Reference Genes
BioGPS Gene:64848 YTHDC2
COSMIC (genes):YTHDC2 YTHDC2
CTD Gene:64848 YTHDC2
dbSNP Gene:64848 YTHDC2
ENSEMBL:ENSG00000047188 YTHDC2
HGNC:24721 YTHDC2
KEGG:hsa:64848 YTHDC2
Monarch:64848 YTHDC2
NCBI Gene:64848 YTHDC2
OMIM:616530 YTHDC2
UCSC:Q9H6S0 YTHDC2
Reference Transcript
RefSeq:XM_017009730.1 YTHDC2
RefSeq:NM_022828.4 YTHDC2
Other Identifiers
11722148_a_at
11722149_a_at
1568680_PM_s_at
1568680_s_at
16988087
205835_PM_s_at
205835_s_at
205836_PM_s_at
205836_s_at
213077_PM_at
213077_at
2824490
2824491
2824492
2824493
2824494
2824495
2824496
2824497
2824499
2824501
2824503
2824504
2824505
2824506
2824507
2824510
2824511
2824512
2824513
2824515
2824516
2824517
2824518
2824520
2824522
2824523
2824524
2824525
2824526
2824527
2824528
2824531
2824532
2824533
2824534
2824535
2824537
2824538
2824539
2824540
2824541
2824542
2824543
2824544
2824545
2824546
2824547
2824548
2824549
2824550
2824551
41398_at
64848
78857_at
8107375
A_14_P131432
A_23_P41732
A_24_P178106
A_33_P3420747
GE55651
GO:0003676
GO:0003723
GO:0003724
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005737
GO:0005783
GO:0007283
GO:0007286
GO:0008186
GO:0016787
GO:0016887
GO:0022414
GO:0030154
GO:0034458
GO:0034612
GO:0035770
GO:0043226
GO:0044829
GO:0048471
GO:0048477
GO:0048599
GO:0048856
GO:0051321
GO:0051729
GO:0060090
GO:0070063
GO:0070555
GO:0140098
GO:0140657
GO:1990247
HMNXSV003038932
HMNXSV003040089
Hs.104916.0.S1_3p_a_at
Hs.104916.1.S1_3p_at
Hs2.382774.1.S1_3p_s_at
ILMN_1725760
TC05000538.hg
g12383069_3p_a_at
Participates
as an output of
RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)
as a component of
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
as an input of
The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 (Homo sapiens)
Inferred To
Dmel\CG8915 [nucleoplasm]
(Drosophila melanogaster)
ythdc2 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of YTHDC2 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of YTHDC2 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of YTHDC2 [nucleoplasm]
(Schizosaccharomyces pombe)
YTHDC2 [nucleoplasm]
(Bos taurus)
YTHDC2 [nucleoplasm]
(Canis familiaris)
YTHDC2 [nucleoplasm]
(Gallus gallus)
YTHDC2 [nucleoplasm]
(Mus musculus)
YTHDC2 [nucleoplasm]
(Sus scrofa)
Ythdc2 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000047188
ENSEMBL
ENSG00000047188
,
ENSP00000161863
,
ENST00000161863
HPA
ENSG00000047188-YTHDC2
GeneCards
YTHDC2
PRO
Q9H6S0
Pharos - Targets
Q9H6S0
GlyGen
Q9H6S0
PDB
6K6U
,
2YU6
,
6LR2
HMDB Protein
HMDBP12010
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40429 RPL13A
2
RPL13A [cytosol]
(R-HSA-72412)
p-RPL13A [cytosol]
(R-HSA-156829)
0.527
3
UniProt:Q15646 OASL
1
OASL [cytosol]
(R-HSA-1015678)
0.527
2
UniProt:P62249 RPS16
2
RPS16 [cytosol]
(R-HSA-72337)
RPS16 [nucleoplasm]
(R-HSA-6791196)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
3
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.527
2
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
UniProt:Q6DKI1 RL7L
0.527
2
UniProt:P79522 PRR3
0.527
2
UniProt:Q96ME7 ZN512
0.527
2
UniProt:Q6AW86 ZNF324B
1
ZNF324B [nucleoplasm]
(R-HSA-3323092)
0.527
2
UniProt:O95503 CBX6
1
CBX6 [nucleoplasm]
(R-HSA-3229071)
0.527
2
UniProt:P84098 RPL19
1
RPL19 [cytosol]
(R-HSA-72424)
0.527
2
UniProt:Q96LW9 ZSC31
0.527
2
UniProt:Q8NAP3 ZBT38
0.527
2
UniProt:Q02543 RPL18A
1
RPL18A [cytosol]
(R-HSA-72422)
0.527
2
UniProt:Q9NZM5 NOP53
0.527
3
UniProt:P62424 RPL7A
1
RPL7A [cytosol]
(R-HSA-72488)
0.527
2
UniProt:P11487 FGF3
1
FGF3 [extracellular region]
(R-HSA-189886)
0.527
2
UniProt:Q7Z398 ZNF550
1
ZNF550 [nucleoplasm]
(R-HSA-1973896)
0.527
3
UniProt:Q9GZY0 NXF2
2
NXF2 [nucleoplasm]
(R-HSA-8932926)
NXF2 [cytosol]
(R-HSA-8932924)
0.527
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q99J34 Q99J34
0.499
2
UniProt:A2AG06 MEIOC
0.499
2
UniProt:P27958-PRO_0000037577
0.463
2
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