Expression of Interferon-alpha and beta

Stable Identifier
R-HSA-994034
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Expression of Interferon-alpha and beta
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The Interferon alpha and beta genes are transcribed and translated yielding IFNA and IFNB which are secreted. This process is positively regulated by Interferon Regulatory Factor 1 and negatively regulated by Interferon Regulatory Factor 2, which compete for binding to the same regulatory element (Harada et al. 1989).
Literature References
PubMed ID Title Journal Year
20627800 Regulation of immune cell homeostasis by type I interferons

Tough, DF, Mattei, F, Schiavoni, G

Cytokine Growth Factor Rev 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IRF2:promoters of INF alpha, INF beta [nucleoplasm] (Homo sapiens)
Active Unit
IRF2 [nucleoplasm]
Positively by
Regulator
IRF1:Promotors of IFN alpha, IFN beta [nucleoplasm] (Homo sapiens)
Active Unit
IRF1 [nucleoplasm]
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-05)
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