Reactome | CBX5 [nucleoplasm]

CBX5 [nucleoplasm]

Stable Identifier

R-HSA-994093

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, CBX5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13112 CAF1B

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of CBX5 with SUMO1 (Homo sapiens)
        
        CBX5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P45973 CBX5

Gene Names

CBX5, HP1A

Chain

chain:1-191

Reference Genes

BioGPS Gene:23468 CBX5

COSMIC (genes):CBX5 CBX5

CTD Gene:23468 CBX5

dbSNP Gene:23468 CBX5

ENSEMBL:ENSG00000094916 CBX5

HGNC:1555 CBX5

KEGG Gene (Homo sapiens):23468 CBX5

Monarch:23468 CBX5

NCBI Gene:23468 CBX5

OMIM:604478 CBX5

Reference Transcript

Other Identifiers

0006380008

0105860341

11716275_a_at

11716276_a_at

11716277_a_at

11716278_s_at

11716279_x_at

11716280_a_at

11740499_a_at

16699

16765513

17548

209715_at

212126_at

226085_at

231862_at

23468

234990_at

3456628

3456629

3456631

3456632

3456633

3456634

3456637

3456639

3456640

3456641

3456642

3456643

3456653

36236_at

3951974

39715_at

3FDT

3I3C

40731_at

44900_at

46565_at

50280_at

51739_r_at

76691_at

7963750

84069_at

84583_at

89500_at

A_23_P2355

A_24_P620621

A_24_P664995

AAA72327

AAB26994

AAC50553

AAH06821

ACJ13653

AK313506

BAG36286

BC006821

CAB017548

CBX5

CBX5-201

CBX5-202

CBX5-204

CCDS8875

CH471054

EAW96759

EAW96760

ENSG00000094916

ENSP00000209875

ENSP00000401009

ENSP00000449207

ENST00000209875

ENST00000209875.8

ENST00000439541

ENST00000439541.6

ENST00000550411

ENST00000550411.5

EntrezGene:23468

EntrezGene:CBX5

EU794599

F8VNY3

g184310_3p_at

GE57575

GE788066

GO:0000118

GO:0000122

GO:0000228

GO:0000775

GO:0000776

GO:0000784

GO:0000792

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005720

GO:0005721

GO:0005730

GO:0006950

GO:0006974

GO:0007049

GO:0007596

GO:0008134

GO:0008150

GO:0009058

GO:0010369

GO:0016032

GO:0016605

GO:0017053

GO:0019899

GO:0030674

GO:0031618

GO:0032991

GO:0034641

GO:0035064

GO:0035097

GO:0042393

GO:0042802

GO:0042803

GO:0042826

GO:0043021

GO:0043226

GO:0044403

GO:0044877

GO:0045892

GO:0070317

GO:0070491

GO:0090734

GO:1990904

HEL25

HGNC:1555

HPA016699

Hs.12484.0.A1_3p_at

Hs.131798.0.S1_3p_at

Hs.131798.0.S1_3p_x_at

Hs.135287.0.A1_3p_at

Hs.306000.1.A1_3p_at

ILMN_1726134

ILMN_1813028

IPR000953

IPR008251

IPR016197

IPR017984

IPR023779

IPR023780

L07515

L07515_at

MIM:604478

NM_001127321

NM_001127322

NM_012117

NP_001120793

NP_001120794

NP_036249

PF00385

PF01393

PH_hs_0024494

PR00504

S62077

SM00298

SM00300

TC12001566.hg

U26311

UPI00001271FC

V9HWG0

Participant Of

input

hasComponent

HP1alpha:Histone H3 methylated at K9 [nucleoplasm]

output

CBX5 gene expression is inhibited by E2F6

Other forms of this molecule

SUMO1-K84,K-CBX5 [nucleoplasm]

Inferred To

Cbx5 [nucleoplasm] (Mus musculus)

Homologues of CBX5 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CBX5 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CBX5 [nucleoplasm] (Drosophila melanogaster)

Homologues of CBX5 [nucleoplasm] (Schizosaccharomyces pombe)

CBX5 [nucleoplasm] (Bos taurus)

CBX5 [nucleoplasm] (Caenorhabditis elegans)

CBX5 [nucleoplasm] (Canis familiaris)

CBX5 [nucleoplasm] (Danio rerio)

CBX5 [nucleoplasm] (Dictyostelium discoideum)

CBX5 [nucleoplasm] (Drosophila melanogaster)

CBX5 [nucleoplasm] (Gallus gallus)

CBX5 [nucleoplasm] (Plasmodium falciparum)

CBX5 [nucleoplasm] (Rattus norvegicus)

CBX5 [nucleoplasm] (Schizosaccharomyces pombe)

CBX5 [nucleoplasm] (Sus scrofa)

CBX5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001120794.1, NP_001120793.1, NP_036249.1

OpenTargets

ENSG00000094916

GeneCards

P45973

PRO

P45973

PDB

3I3C, 3FDT

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.908	10
UniProt:Q13263 TRIM28	2	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998)	0.829	10
UniProt:Q9BWN1 PRR14			0.829	6
UniProt:P68431 HIST1H3A	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.811	10
UniProt:Q9NQS7 INCENP	2	INCENP [cytosol] (R-HSA-375311) INCENP [nucleoplasm] (R-HSA-4655393)	0.798	11
UniProt:Q13111 CAF1A			0.733	7
UniProt:Q9H410 DSN1	3	DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228) DSN1 [cytosol] (R-HSA-375308)	0.725	6
UniProt:Q7Z3K3 POGZ			0.722	7
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) SUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.702	6
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.669	3
UniProt:Q9BQF6 SENP7			0.669	4
UniProt:Q9H2P0 ADNP			0.669	3
UniProt:P23497-2 SP100			0.666	6
UniProt:Q5T3J3 LRIF1			0.659	3
UniProt:Q96JM3 CHAP1			0.643	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	4
UniProt:Q13112 CAF1B			0.643	5
UniProt:P83916 CBX1			0.643	4
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.643	4
UniProt:Q14739 LBR	1	LBR [nuclear envelope] (R-HSA-194637)	0.605	4
UniProt:Q5ZUS4 Q5ZUS4			0.593	6
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.573	2
UniProt:Q16695 HIST3H3	3	Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186) HIST3H3 [nucleoplasm] (R-HSA-181914)	0.564	2
UniProt:P62805 HIST1H4A	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.564	2
UniProt:P84243 H3F3A	15	MeK-H3F3A [nucleoplasm] (R-HSA-427369) H3F3A [extracellular region] (R-HSA-977567) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [nucleoplasm] (R-HSA-212295) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.558	2
UniProt:Q6N043 Z280D			0.527	2
UniProt:Q96CS4 ZNF689	1	ZNF689 [nucleoplasm] (R-HSA-2248889)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q5TGY3 AHDC1			0.527	2
UniProt:Q6AHZ1 Z518A			0.527	2
UniProt:Q96JM2 ZN462			0.527	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	2
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.527	2
UniProt:Q8N9R8 SCAI	1	SCAI [nucleoplasm] (R-HSA-5666012)	0.527	2
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.527	2
UniProt:Q6P1K2 PMF1	1	PMF1 [cytosol] (R-HSA-375320)	0.527	2
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q13129 RLF			0.527	2
UniProt:Q9Y6X3 MAU2	1	MAU2 [nucleoplasm] (R-HSA-1629801)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	2
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.527	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.527	2
IntAct:EBI-15634422 H3K9-2			0.499	2
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) SUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.499	3
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q6N043-2 ZNF280D			0.488	2
UniProt:Q8ND82 Z280C			0.488	2
UniProt:P28838 AMPL			0.488	4
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.488	2
UniProt:Q6KC79 NIPBL	1	NIPBL [nucleoplasm] (R-HSA-2506879)	0.482	2
UniProt:Q9UHL9 GT2D1			0.463	2