ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5

Stable Identifier
R-HSA-994137
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate inositol polyphosphates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels.

Literature References
PubMed ID Title Journal Year
8662638 Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme

Wilson, MP, Majerus, PW

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol tetrakisphosphate 1-kinase activity of ITPK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed