ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5

Stable Identifier
R-HSA-994137
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Summation

Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate inositol polyphosphates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels.

Literature References
PubMed ID Title Journal Year
8662638 Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme

Wilson, MP, Majerus, PW

J Biol Chem 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
inositol tetrakisphosphate 1-kinase activity of ITPK1 [cytosol]
Physical Entity
ITPK1 [cytosol]
Activity
inositol tetrakisphosphate 1-kinase activity (0047325)
Orthologous Events
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Arabidopsis thaliana)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Oryza sativa)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Taeniopygia guttata)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)
Cross References
Rhea
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)