ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5

Stable Identifier
R-HSA-994137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5
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Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate inositol polyphosphates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels.
Literature References
PubMed ID Title Journal Year
8662638 Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme

Majerus, PW, Wilson, MP

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-3,4,5,6-tetrakisphosphate 1-kinase activity of ITPK1 [cytosol]

Physical Entity
ITPK1 [cytosol] (Homo sapiens)
Activity
inositol-3,4,5,6-tetrakisphosphate 1-kinase activity (GO:0047325)
Orthologous Events
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Bos taurus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Gallus gallus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Mus musculus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Sus scrofa)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Xenopus tropicalis)
Cross References
Rhea
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-05)
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