ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5

Stable Identifier
R-HSA-994137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate inositol polyphosphates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels.
Literature References
PubMed ID Title Journal Year
8662638 Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme

Majerus, PW, Wilson, MP

J Biol Chem 1996
Participants
Participates
Catalyst Activity

inositol tetrakisphosphate 1-kinase activity of ITPK1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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