LRRC16A binds F-actin capping protein

Stable Identifier
R-HSA-994148
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Leucine rich repeat-containing protein 16A (CARMIL homolog) binds F-actin capping protein (CP) with high affinity, significantly decreasing the affinity of CP for actin barbed ends. Actin polymerization occurs at the barbed end; proteins like CP that cap the barbed end inhibit elongation. Inhibition of CP therefore enhances the rate of barbed-end actin polymerization. In cells, GFP-LRRC16A was seen to be concentrated in lamellipodia and increased the fraction of cells with large lamellipodia. Decreasing LRRC16A levels with siRNA lowered F-actin levels, decreased lamellipodia protrusion and slowed cell migration.

Literature References
PubMed ID Title Journal Year
16054028 Mammalian CARMIL inhibits actin filament capping by capping protein

Yang, C, Pring, M, Wear, MA, Huang, M, Cooper, JA, Svitkina, TM, Zigmond, SH

Dev Cell 2005
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