TBX21 positively regulates expression of Tumor necrosis factor (TNF)

Stable Identifier
R-HSA-9942923
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In T helper 1 cells (Th1 cells), TBX21 upregulates expression of the pro-inflammatory cytokine Tumor necrosis factor (TNF) (Jenner et al. 2009, Henderson et al. 2021).
Literature References
PubMed ID Title Journal Year
34531288 The Th1 cell regulatory circuitry is largely conserved between human and mouse

Henderson, S, Pullabhatla, V, Hertweck, A, de Rinaldis, E, Herrero, J, Lord, GM, Jenner, RG

Life Sci Alliance 2021
19805038 The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Jenner, RG, Townsend, MJ, Jackson, I, Sun, K, Bouwman, RD, Young, RA, Glimcher, LH, Lord, GM

Proc Natl Acad Sci U S A 2009
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!