TBX21 positively regulates expression of Tumor necrosis factor (TNF)

Stable Identifier
R-HSA-9942923
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TBX21 positively regulates expression of Tumor necrosis factor (TNF)
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In T helper 1 cells (Th1 cells), TBX21 upregulates expression of the pro-inflammatory cytokine Tumor necrosis factor (TNF) (Jenner et al. 2009, Henderson et al. 2021).
Literature References
PubMed ID Title Journal Year
34531288 The Th1 cell regulatory circuitry is largely conserved between human and mouse

Henderson, S, Pullabhatla, V, Hertweck, A, de Rinaldis, E, Herrero, J, Lord, GM, Jenner, RG

Life Sci Alliance 2021
19805038 The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Jenner, RG, Townsend, MJ, Jackson, I, Sun, K, Bouwman, RD, Young, RA, Glimcher, LH, Lord, GM

Proc Natl Acad Sci U S A 2009
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
TBX21:TNF gene [nucleoplasm] (Homo sapiens)
Active Unit
TBX21 [nucleoplasm]
Authored
May, B  (2025-03-19)
Reviewed
Barbutti, I  (2025-08-04)
Lord, GM  (2025-08-05)
Created
May, B  (2025-03-19)
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