AGT(25-31) is decarboxylated to yield Alamandine

Stable Identifier
R-HSA-9944473
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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AGT(25-31) is decarboxylated to yield Alamandine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
AGT(25-31) (Angiotensin (1-7) ) is decarboxylated by an unknown enzyme to yield Alamandine (Lautner et al. 2013). In the reaction, the N-terminal aspartate of AGT(25-31) is converted to an alanine residue, yielding Ala-Arg-Val-Tyr-Ile-His-Pro. Alamandine binds the receptor MRGPRD (MrgD) and shows vasodilatory effects. Alamandine may therefore be a part of the counter-regulatory (antihypertensive, anti-inflammatory) axis of the renin-angiotensin system (Lautner et al. 2013, reviewed in Bader et al. 2024, Proença et al. 2024).
Literature References
PubMed ID Title Journal Year
23446738 Discovery and characterization of alamandine: a novel component of the renin-angiotensin system

Lautner, RQ, Villela, DC, Fraga-Silva, RA, Silva, N, Verano-Braga, T, Costa-Fraga, F, Jankowski, J, Jankowski, V, Sousa, F, Alzamora, A, Soares, E, Barbosa, C, Kjeldsen, F, Oliveira, A, Braga, J, Savergnini, S, Maia, G, Peluso, AB, Passos-Silva, D, Ferreira, A, Alves, F, Martins, A, Raizada, M, Paula, R, Motta-Santos, D, Klempin, F, Pimenta, A, Alenina, N, Sinisterra, R, Bader, M, Campagnole-Santos, MJ, Santos, RA

Circ Res 2013
Participants
Input
Output
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as an event of
Authored
May, B  (2025-04-04)
Reviewed
Bader, M  (2025-04-20)
Santos, RAS  (2025-04-20)
Touyz, RM  (2025-04-20)
Created
May, B  (2025-04-05)
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