ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)

Stable Identifier
R-HSA-9944488
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)
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ACE2 cleaves the C-terminal phenylalanine residue from 1-Ala-AGT(34-41) (Angiotensin A, amino acid sequence Ala-Arg-Val-Tyr-Ile-His-Pro-Phe) to yield Alamandine (1-Ala-AGT(34-40), amino acid sequence Ala-Arg-Val-Tyr-Ile-His-Pro) (Lautner et al. 2013). Alamandine binds the receptor MRGPRD (MrgD) and may form part of the counter-regulatory (anti-hypertensive, anti-inflammatory) axis of renin-angiotensin signaling (reviewed in Bader et al. 2024, Proença et al. 2024).
Literature References
PubMed ID Title Journal Year
23446738 Discovery and characterization of alamandine: a novel component of the renin-angiotensin system

Lautner, RQ, Villela, DC, Fraga-Silva, RA, Silva, N, Verano-Braga, T, Costa-Fraga, F, Jankowski, J, Jankowski, V, Sousa, F, Alzamora, A, Soares, E, Barbosa, C, Kjeldsen, F, Oliveira, A, Braga, J, Savergnini, S, Maia, G, Peluso, AB, Passos-Silva, D, Ferreira, A, Alves, F, Martins, A, Raizada, M, Paula, R, Motta-Santos, D, Klempin, F, Pimenta, A, Alenina, N, Sinisterra, R, Bader, M, Campagnole-Santos, MJ, Santos, RA

Circ Res 2013
Participants
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Output
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as an event of
Catalyst Activity

metallocarboxypeptidase activity of ACE2(18-805):Zn2+ dimer [plasma membrane]

Physical Entity
ACE2(18-805):Zn2+ dimer [plasma membrane] (Homo sapiens)
Activity
metallocarboxypeptidase activity (GO:0004181)
Authored
May, B  (2025-04-04)
Reviewed
Bader, M  (2025-04-20)
Santos, RAS  (2025-04-20)
Touyz, RM  (2025-04-20)
Created
May, B  (2025-04-05)
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