AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)

Stable Identifier
R-HSA-9944540
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)
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A decarboxylated derivative of AGT(25-32) (Angiotensin-(1-8)) designated Angiotensin A (Ang A) was discovered circulating in human blood (Jankowski et al. 2007). The N-terminal aspartate residue of AGT(25-32) is decarboxylated to yield an alanine residue, thus the sequence of Ang A is Ala-Arg-Val-Tyr-Ile-His-Pro-Phe. The enzyme that catalyzes the decarboxylation reaction is not yet identified.
The C-terminal phenylalanine residue of Ang A is cleaved by ACE2, yielding Alamandine, a ligand of MRGPRD (MrgD) which may act in the counter-regulatory (anti-hypertensive, anti-inflammatory) axis of the renin-angiotensin system (reviewed in Bader et al. 2024, Proença et al. 2024).
Literature References
PubMed ID Title Journal Year
17138938 Mass-spectrometric identification of a novel angiotensin peptide in human plasma

Jankowski, V, Vanholder, R, van der Giet, M, Tölle, M, Karadogan, S, Gobom, J, Furkert, J, Oksche, A, Krause, E, Tran, TN, Tepel, M, Schuchardt, M, Schlüter, H, Wiedon, A, Beyermann, M, Bader, M, Todiras, M, Zidek, W, Jankowski, J

Arterioscler Thromb Vasc Biol 2007
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Authored
May, B  (2025-04-04)
Reviewed
Bader, M  (2025-04-20)
Santos, RAS  (2025-04-20)
Touyz, RM  (2025-04-20)
Created
May, B  (2025-04-05)
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