Alamandine binds MRGPRD (MrgD)

Stable Identifier
R-HSA-9944544
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Alamandine binds MRGPRD (MrgD)
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Alamandine is a decarboxylated form of the heptapeptide AGT(25-31) (Angiotensin-(1-7), amino acid sequence Ala-Arg-Val-Tyr-Ile-His-Pro) that binds the G protein coupled receptor MRGPRD (MrgD) (Lautner et al.2013). The binding of Alamandine to MRGPRD causes cellular release of nitric oxide, a vasodilator (Lautner et al. 2013). Alamandine also interacts with a MAS1:MRGPRD heterodimer (Rukavina Mikusic et al. 2024). MRGPRD interacts with Galpha(i) (Suzuki et al. 2022) and Galpha(q) (Wang et al. 2024). Alamanidine and MRGPRD are components of the counter-regulatory system within the renin-angiotensin system (reviewed in Bader et al. 2024, Proença et al. 2024), however, their physiological roles are not well characterized.
Literature References
PubMed ID Title Journal Year
23446738 Discovery and characterization of alamandine: a novel component of the renin-angiotensin system

Lautner, RQ, Villela, DC, Fraga-Silva, RA, Silva, N, Verano-Braga, T, Costa-Fraga, F, Jankowski, J, Jankowski, V, Sousa, F, Alzamora, A, Soares, E, Barbosa, C, Kjeldsen, F, Oliveira, A, Braga, J, Savergnini, S, Maia, G, Peluso, AB, Passos-Silva, D, Ferreira, A, Alves, F, Martins, A, Raizada, M, Paula, R, Motta-Santos, D, Klempin, F, Pimenta, A, Alenina, N, Sinisterra, R, Bader, M, Campagnole-Santos, MJ, Santos, RA

Circ Res 2013
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Authored
May, B  (2025-04-04)
Reviewed
Bader, M  (2025-04-20)
Touyz, RM  (2025-04-20)
Santos, RAS  (2025-04-20)
Created
May, B  (2025-04-05)
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