Reactome | K63polyUb-K138,K139-RPS10 [cytosol]

K63polyUb-K138,K139-RPS10 [cytosol]

Stable Identifier

R-HSA-9948298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="13"Small ribosomal subunit protein eS10, RS10_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46783 RPS10

Gene Names

RPS10

Chain

chain:1-165

Reference Genes

BioGPS Gene:6204 RPS10

COSMIC (genes):RPS10 RPS10

CTD Gene:6204 RPS10

dbSNP Gene:6204 RPS10

ENSEMBL:ENSG00000124614 RPS10

HGNC:10383 RPS10

KEGG:hsa:6204 RPS10

Monarch:6204 RPS10

NCBI Entrez Gene:6204 RPS10

OMIM:603632 RPS10

UCSC:P46783 RPS10

Reference Transcript

Other Identifiers

11757758_x_at

11758313_x_at

16651541

16651543

16651545

16651547

16651549

16651551

16651559

16651561

16651567

16651569

18670518

18670519

18670520

18670521

18670522

18670523

18670524

200095_PM_x_at

200095_x_at

200817_PM_x_at

200817_x_at

211542_PM_x_at

211542_x_at

2904163

2951151

2951152

2951153

2951154

2951155

2951156

2951159

2951160

2951161

2951163

2951164

2951165

2951166

2951167

2951168

2951169

2951170

2951171

2951172

2951173

2951174

2997677

3071773

3071779

3147060

31568_at

3371638

3371639

3371640

3371642

3834922

6204

7894070

7895324

7895690

7896095

8125835

A_23_P356484

GE580734

GE85992

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0016020

GO:0022626

GO:0022627

GO:0045202

GO:1990904

HMNXSV003017261

Hs.76230.2.S1_3p_x_at

ILMN_1686954

PH_hs_0030063

TC06004130.hg

U14972_at

Participates

as a component of

K63polyUb-40S ribosomal subunit [cytosol] (Homo sapiens)

Other forms of this molecule

RPS10 [cytosol]

RPS10 [nucleoplasm]

Inferred To

K63polyUb-K138,K139-RPS10 [cytosol] (Plasmodium falciparum)

RPS10A [cytosol] (Saccharomyces cerevisiae)

Rps10 [cytosol] (Mus musculus)

Rps10 [cytosol] (Rattus norvegicus)

rps10 [cytosol] (Danio rerio)

rps10 [cytosol] (Dictyostelium discoideum)

rps10 [cytosol] (Xenopus tropicalis)

rps-10 [cytosol] (Caenorhabditis elegans)

RpS10b [cytosol] (Drosophila melanogaster)

RPS10 [cytosol] (Bos taurus)

RPS10 [cytosol] (Canis familiaris)

RPS10 [cytosol] (Gallus gallus)

RPS10 [cytosol] (Sus scrofa)

rps1002 [cytosol] (Schizosaccharomyces pombe)

Homologues of K63polyUb-K138,K139-RPS10 [cytosol] (Saccharomyces cerevisiae)

RPS10B [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 138

Coordinate

138

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 139

Coordinate

139

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001191020.1, NP_001005.1, NP_001190174.1

OpenTargets

ENSG00000124614

ENSEMBL

ENSP00000494440, ENSP00000497917, ENST00000621356, ENSG00000124614, ENST00000648437, ENST00000467531, ENSP00000481646, ENST00000464218, ENSP00000494190

HPA

ENSG00000124614-RPS10

GeneCards

RPS10

PRO

P46783

Pharos - Targets

P46783

Orphanet

RPS10

GlyGen

P46783

PDB

8XP3, 7TQL, 8YOO, 8PJ1, 9BLN, 6ZXG, 5LKS, 4UG0, 7QP7, 7K5I, 8PJ6, 5OA3, 8XXL, 6OLG, 8JDM, 8PJ2, 6Y0G, 8GLP, 6Y2L, 6ZOL, 7XNY, 8IFE, 6G53, 8XSZ, 6ZVJ, 6ZN5, 6FEC, 9G8M, 6ZXD, 8UKB, 8XP2, 7QP6, 6IP5, 8IFD, 6ZP4, 6OLZ, 8Y0X, 8G61, 8PPL, 6ZM7, 8PJ5, 6OLE, 8JDL, 6G5H, 6YBS, 9C3H, 8XSY, 6G51, 8XSX, 6ZV6, 6ZMT, 8QOI, 8ZDC, 6Z6M, 8OZ0, 6ZXE, 6ZXH, 7QVP, 6OM7, 9G8O, 6IP6, 8YOP, 8G60, 6OLF, 8XXN, 6G5I, 8JDK, 5A2Q, 9BKD, 7A09, 6OM0, 8K2C, 7XNX, 6Z6N, 5FLX, 6ZOJ, 5VYC, 5T2C, 8ZDB, 6ZMI, 6IP8, 6ZLW, 6ZXF, 6Y57, 8G6J, 6ZON, 4V6X, 6ZUO, 8G5Y, 8Y0W, 8PJ3, 6XA1, 8JDJ, 8XXM, 7R4X, 8PJ4, 8PPK, 5AJ0, 8T4S, 6OLI, 6ZME, 6ZVH, 6ZMO, 6QZP, 6Z6L, 6ZMW, 8ZDD

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.725	5
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.715	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	7
UniProt:Q9H2U1 DHX36	1	DHX36 [cytosol] (R-HSA-3134862)	0.527	2
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q9P031 CCDC59	1	CCDC59 [nucleoplasm] (R-HSA-5683813)	0.527	2
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	3
UniProt:Q5VYS8 TUT7	1	TUT7 [cytosol] (R-HSA-8941313)	0.527	2
UniProt:Q9BYK8 HELZ2	1	HELZ2 [nucleoplasm] (R-HSA-442499)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.527	2
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3

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