Reactome | GATA2 [nucleoplasm]

GATA2 [nucleoplasm]

Stable Identifier

R-HSA-996735

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Endothelial transcription factor GATA-2, GATA2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        RUNX1 binds the core TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
        
        GATA2 [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
        
        GATA2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23769 GATA2

Gene Names

GATA2

Chain

chain:1-480

Reference Genes

BioGPS Gene:2624 P237692

COSMIC (genes):GATA2 GATA2

CTD Gene:2624 P237692

dbSNP Gene:2624 GATA2

ENSEMBL:ENSG00000179348 GATA2

HGNC:4171 P237692

KEGG:hsa:2624 P237692

Monarch:2624 P237692

NCBI Gene:2624 P237692

OMIM:137295 P237692

UCSC:P23769 P237692

Reference Transcript

Participates

as a member of

as a component of

CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)

as an input of

RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)

Inferred To

gata2a [nucleoplasm] (Danio rerio)

srp [nucleoplasm] (Drosophila melanogaster)

Homologues of GATA2 [nucleoplasm] (Drosophila melanogaster)

GATAe [nucleoplasm] (Drosophila melanogaster)

Gata2 [nucleoplasm] (Mus musculus)

Gata2 [nucleoplasm] (Rattus norvegicus)

GATA2 [nucleoplasm] (Bos taurus)

GATA2 [nucleoplasm] (Canis familiaris)

GATA2 [nucleoplasm] (Gallus gallus)

GATA2 [nucleoplasm] (Sus scrofa)

GATAd [nucleoplasm] (Drosophila melanogaster)

gata2 [nucleoplasm] (Xenopus tropicalis)

grn [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001139134.1, NP_001139133.1, NP_116027.2

OpenTargets

ENSG00000179348

ENSEMBL

ENSP00000345681, ENST00000430265, ENSG00000179348, ENST00000341105, ENST00000487848, ENSP00000417074, ENSP00000400259

HPA

ENSG00000179348-GATA2

GeneCards

GATA2

PRO

P23769

Pharos - Targets

P23769

GlyGen

P23769

Orphanet

GATA2

HMDB Protein

HMDBP13411

PDB

5O9B, 6ZFV

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.776	10
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.666	4
UniProt:Q13643 FHL3			0.666	5
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.666	4
UniProt:P36406 TRI23			0.666	4
UniProt:Q99750 MDFI			0.666	4
UniProt:P17947 SPI1	1	SPI1 [nucleoplasm] (R-HSA-8865503)	0.639	4
IntAct:EBI-10171679 386682			0.601	4
UniProt:P25801	1	Lmo2 [nucleoplasm] (R-MMU-8956513)	0.593	3
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.571	2
UniProt:P35548 MSX2	1	MSX2 [nucleoplasm] (R-HSA-9007760)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q93062-3 RBPMS			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q3SY46 KRTAP13-3	1	KRTAP13-3 [cytosol] (R-HSA-6810267)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q3LI59 KRTAP21-2	1	KRTAP21-2 [cytosol] (R-HSA-6810245)	0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q8IUC1 KRTAP11-1	1	KRTAP11-1 [cytosol] (R-HSA-6810294)	0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
UniProt:P86479 PR20C			0.556	3
UniProt:Q8IUC3 KRA71			0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:P08651 NFIC	1	NFIC [nucleoplasm] (R-HSA-60138)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2
UniProt:O00712 NFIB	1	NFIB [nucleoplasm] (R-HSA-60136)	0.471	2

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