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GATA2 [nucleoplasm]
Stable Identifier
R-HSA-996735
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Endothelial transcription factor GATA-2, GATA2_HUMAN
Locations in the PathwayBrowser for interactor IntAct:EBI-10171679
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
GATA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23769 GATA2
Gene Names
GATA2
Chain
chain:1-480
Reference Genes
BioGPS Gene:2624 GATA2
COSMIC (genes):GATA2 GATA2
CTD Gene:2624 GATA2
dbSNP Gene:2624 GATA2
ENSEMBL:ENSG00000179348 GATA2
HGNC:4171 GATA2
KEGG Gene (Homo sapiens):2624 GATA2
Monarch:2624 GATA2
NCBI Gene:2624 GATA2
OMIM:137295 GATA2
UCSC:P23769 GATA2
Reference Transcript
RefSeq:NM_001145661.1 GATA2
RefSeq:NM_001145662.1 GATA2
RefSeq:NM_032638.4 GATA2
Other Identifiers
0005290133
1072_g_at
11722761_a_at
11722762_a_at
11722763_s_at
11728946_x_at
11752208_a_at
16958844
203_at
209710_at
210358_3p_x_at
210358_x_at
2624
2694316
2694317
2694318
2694319
2694320
2694321
2694322
2694323
2694326
2694329
2694330
2694331
2694332
2694333
2694334
2694335
2694336
2694337
2694338
2694348
2694349
2694350
2694351
37194_at
8090469
A_23_P110022
A_24_P165998
A_33_P3550894
GE83465
GE87399
GO:0000003
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0001655
GO:0001709
GO:0001764
GO:0001892
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0006355
GO:0006357
GO:0006464
GO:0006810
GO:0006909
GO:0006950
GO:0007165
GO:0007204
GO:0007596
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0010725
GO:0016192
GO:0021514
GO:0021533
GO:0021700
GO:0021902
GO:0021954
GO:0021983
GO:0030097
GO:0030154
GO:0030182
GO:0032991
GO:0033993
GO:0034641
GO:0035019
GO:0035065
GO:0035854
GO:0040011
GO:0042472
GO:0042592
GO:0043167
GO:0043226
GO:0043306
GO:0043536
GO:0043565
GO:0045165
GO:0045599
GO:0045638
GO:0045648
GO:0045650
GO:0045654
GO:0045666
GO:0045746
GO:0045766
GO:0045944
GO:0046872
GO:0048469
GO:0048646
GO:0048663
GO:0048856
GO:0048870
GO:0048873
GO:0050766
GO:0051276
GO:0060100
GO:0060216
GO:0060872
GO:0061024
GO:0061042
GO:0070345
GO:0070742
GO:0090050
GO:0090102
GO:0097154
GO:1902036
GO:1902895
GO:1903589
GO:1990837
GO:2000178
GO:2000352
GO:2000977
HMNXSV003052504
Hs.760.1.S2_3p_at
ILMN_1726196
ILMN_2102670
M68891_at
PH_hs_0017514
TC03001755.hg
g12803464_3p_a_at
g12803464_3p_x_at
g4503926_3p_a_at
Participates
as a member of
GATA proteins [nucleoplasm] (Homo sapiens)
GATA1,GATA2,GATA3 [nucleoplasm] (Homo sapiens)
as a component of
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
as an input of
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
Inferred To
gata2a [nucleoplasm]
(Danio rerio)
srp [nucleoplasm]
(Drosophila melanogaster)
Homologues of GATA2 [nucleoplasm]
(Drosophila melanogaster)
Gata2 [nucleoplasm]
(Mus musculus)
Gata2 [nucleoplasm]
(Rattus norvegicus)
GATA2 [nucleoplasm]
(Bos taurus)
GATA2 [nucleoplasm]
(Canis familiaris)
GATA2 [nucleoplasm]
(Gallus gallus)
GATA2 [nucleoplasm]
(Sus scrofa)
GATAd [nucleoplasm]
(Drosophila melanogaster)
grn [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_116027.2
,
NP_001139134.1
,
NP_001139133.1
OpenTargets
ENSG00000179348
GeneCards
P23769
HPA
ENSG00000179348-GATA2
Ensembl
ENST00000487848
,
ENSP00000345681
,
ENST00000341105
,
ENST00000430265
,
ENSP00000417074
,
ENSP00000400259
,
ENSG00000179348
PRO
P23769
Orphanet
20311
PDB
5O9B
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13643 FHL3
0.666
5
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.666
4
UniProt:P36406 TRI23
0.666
4
UniProt:Q7Z3S9 NT2NA
0.666
4
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.666
4
UniProt:Q99750 MDFI
0.666
4
UniProt:P17947 SPI1
1
SPI1 [nucleoplasm]
(R-HSA-8865503)
0.639
4
IntAct:EBI-10171679 386682
0.601
4
UniProt:P25801
1
Lmo2 [nucleoplasm]
(R-MMU-8956513)
0.593
3
UniProt:Q8IUC3 KRA71
0.556
3
UniProt:P86479 PR20C
0.556
3
UniProt:Q8IUC2 KRTAP8-1
1
KRTAP8-1 [cytosol]
(R-HSA-6810288)
0.556
3
UniProt:Q8IUC1 KRTAP11-1
1
KRTAP11-1 [cytosol]
(R-HSA-6810294)
0.556
3
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
UniProt:Q3LI59 KRTAP21-2
1
KRTAP21-2 [cytosol]
(R-HSA-6810245)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
3
UniProt:P35548 MSX2
1
MSX2 [nucleoplasm]
(R-HSA-9007760)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q93062-3 RBPMS
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
IntAct:EBI-22311199 CCSB ORF ID
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q13485 SMAD4
88
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
SMAD4 E417* [cytosol]
(R-HSA-9675623)
SMAD4 Y195* [cytosol]
(R-HSA-9678462)
SMAD4 E108* [cytosol]
(R-HSA-9675640)
SMAD4 S343* [cytosol]
(R-HSA-9675641)
SMAD4 E520* [cytosol]
(R-HSA-9675636)
SMAD4 G510* [cytosol]
(R-HSA-9678452)
SMAD4 G358* [cytosol]
(R-HSA-9678453)
SMAD4 E175* [cytosol]
(R-HSA-9675637)
SMAD4 E307* [cytosol]
(R-HSA-9675639)
SMAD4 E53* [cytosol]
(R-HSA-9675633)
SMAD4 S171* [cytosol]
(R-HSA-9675634)
SMAD4 G30* [cytosol]
(R-HSA-9678450)
SMAD4 G168* [cytosol]
(R-HSA-9678451)
SMAD4 Q366* [cytosol]
(R-HSA-9675200)
SMAD4 R135* [cytosol]
(R-HSA-9675090)
SMAD4 L146* [cytosol]
(R-HSA-9678509)
SMAD4 L440* [cytosol]
(R-HSA-9678510)
SMAD4 Q183* [cytosol]
(R-HSA-9675176)
SMAD4 Q289* [cytosol]
(R-HSA-9675177)
SMAD4 Q248* [cytosol]
(R-HSA-9675178)
SMAD4 Q249* [cytosol]
(R-HSA-9675172)
SMAD4 Q256* [cytosol]
(R-HSA-9675173)
SMAD4 Q239* [cytosol]
(R-HSA-9675174)
SMAD4 Q245* [cytosol]
(R-HSA-9675175)
SMAD4 Q224* [cytosol]
(R-HSA-9675168)
SMAD4 W509* [cytosol]
(R-HSA-9678497)
SMAD4 Q311* [cytosol]
(R-HSA-9675169)
SMAD4 W398* [cytosol]
(R-HSA-9678498)
SMAD4 Q250* [cytosol]
(R-HSA-9675170)
SMAD4 Q410* [cytosol]
(R-HSA-9675196)
SMAD4 Q534* [cytosol]
(R-HSA-9675197)
SMAD4 Q83* [cytosol]
(R-HSA-9675199)
SMAD4 Q448* [cytosol]
(R-HSA-9675192)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 Q455* [cytosol]
(R-HSA-9675193)
SMAD4 R445* [cytosol]
(R-HSA-9675065)
SMAD4 Q442* [cytosol]
(R-HSA-9675194)
SMAD4 Q516* [cytosol]
(R-HSA-9675195)
SMAD4 C443* [cytosol]
(R-HSA-9678523)
SMAD4 Q334* [cytosol]
(R-HSA-9675191)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 L172* [cytosol]
(R-HSA-9678514)
SMAD4 K122* [cytosol]
(R-HSA-9678515)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 Y430* [cytosol]
(R-HSA-9678476)
SMAD4 Y260* [cytosol]
(R-HSA-9678477)
SMAD4 Y95* [cytosol]
(R-HSA-9678478)
SMAD4 Y322* [cytosol]
(R-HSA-9678479)
SMAD4 E321* [cytosol]
(R-HSA-9675658)
SMAD4 Y412* [cytosol]
(R-HSA-9678469)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 Y328* [cytosol]
(R-HSA-9678470)
SMAD4 E33* [cytosol]
(R-HSA-9675654)
SMAD4 Y513* [cytosol]
(R-HSA-9678471)
SMAD4 E526* [cytosol]
(R-HSA-9675648)
SMAD4 S138* [cytosol]
(R-HSA-9675649)
SMAD4 Y276* [cytosol]
(R-HSA-9678466)
SMAD4 E205* [cytosol]
(R-HSA-9675650)
SMAD4 E49* [cytosol]
(R-HSA-9675651)
SMAD4 W101* [cytosol]
(R-HSA-9678492)
SMAD4 W268* [cytosol]
(R-HSA-9678494)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 W524* [cytosol]
(R-HSA-9678491)
SMAD4 W302* [cytosol]
(R-HSA-9678490)
SMAD4 S242* [cytosol]
(R-HSA-9675167)
SMAD4 Q116* [cytosol]
(R-HSA-9675166)
0.508
2
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