Reactome | KDM1A [nucleoplasm]

KDM1A [nucleoplasm]

Stable Identifier

R-HSA-996769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lysine-specific histone demethylase 1A, KDM1A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q99996 AKAP9

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External Reference Information

External Reference

UniProt:O60341 KDM1A

Gene Names

KDM1A, AOF2, KDM1, KIAA0601, LSD1

Chain

chain:1-852

Reference Genes

BioGPS Gene:23028 KDM1A

COSMIC (genes):KDM1A KDM1A

CTD Gene:23028 KDM1A

dbSNP Gene:23028 KDM1A

ENSEMBL:ENSG00000004487 KDM1A

HGNC:29079 KDM1A

KEGG Gene (Homo sapiens):23028 KDM1A

Monarch:23028 KDM1A

NCBI Gene:23028 KDM1A

OMIM:609132 KDM1A

UCSC:O60341 KDM1A

Reference Transcript

Other Identifiers

0006940563

11719325_s_at

16660624

212348_s_at

23028

2325005

2325006

2325008

2325009

2325013

2325014

2325015

2325017

2325018

2325019

2325020

2325021

2325025

2325026

2325027

2325031

2325032

2325033

2325035

2325036

2325039

2325040

2COM

2DW4

2EJR

2H94

2HKO

2IW5

2L3D

2UXN

2UXX

2V1D

2X0L

2XAF

2XAG

2XAH

2XAJ

2XAQ

2XAS

2Y48

2Z3Y

2Z5U

3ABT

3ABU

3ZMS

3ZMT

3ZMU

3ZMV

3ZMZ

3ZN0

3ZN1

41122_at

4BAY

4CZZ

4KUM

4UV8

4UV9

4UVA

4UVB

4UVC

4UXN

4XBF

53660

5884

5AFW

5H6Q

5H6R

5IT3

5L3B

5L3C

5L3D

5L3E

5L3F

5L3G

5LBQ

5LGN

5LGT

5LGU

5LHG

5LHH

5LHI

5X60

5YJB

6NQM

6NQU

7898833

A_14_P136995

A_24_P74981

AAH16639

AAH25362

AAH40194

AAH48134

AB011173

AL031428

AL833812

BAA25527

BC016639

BC025362

BC040194

BC048134

CAB005884

CAD38675

CCDS30627

CCDS53278

ENSG00000004487

ENSP00000349049

ENSP00000383042

ENST00000356634

ENST00000356634.7

ENST00000400181

ENST00000400181.8

EntrezGene:23028

EntrezGene:KDM1A

GE56085

GO:0000122

GO:0000228

GO:0000380

GO:0000784

GO:0000790

GO:0001085

GO:0002039

GO:0002052

GO:0003674

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006259

GO:0006325

GO:0006355

GO:0006357

GO:0006397

GO:0006464

GO:0006482

GO:0006950

GO:0007165

GO:0007275

GO:0007596

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0010569

GO:0010976

GO:0014070

GO:0016491

GO:0019899

GO:0021700

GO:0021987

GO:0030154

GO:0030374

GO:0032091

GO:0032451

GO:0032452

GO:0032453

GO:0032454

GO:0032991

GO:0033169

GO:0033184

GO:0034641

GO:0034644

GO:0034648

GO:0034720

GO:0035563

GO:0042162

GO:0042551

GO:0042592

GO:0043167

GO:0043226

GO:0043392

GO:0043426

GO:0043433

GO:0043518

GO:0044212

GO:0044281

GO:0045793

GO:0045892

GO:0045944

GO:0046098

GO:0048856

GO:0050660

GO:0050681

GO:0051091

GO:0051276

GO:0051572

GO:0051573

GO:0055001

GO:0055114

GO:0060992

GO:0061752

GO:0071320

GO:0071480

GO:0120162

GO:1902166

GO:1903827

GO:1990391

GO:2000179

GO:2000648

HGNC:29079

HPA053660

Hs.174174.0.A1_3p_s_at

ILMN_1813840

IPR002937

IPR007526

IPR009057

IPR017366

IPR036188

IPR036388

KDM1A

KDM1A-201

KDM1A-202

MIM:609132

MIM:616728

NM_001009999

NM_015013

NP_001009999

NP_055828

PF01593

PF04433

PH_hs_0023914

R4GMP9

R4GMQ1

TC01000292.hg

UPI000020466D

UPI0000403137

XM_005245786

XM_006710473

XM_017000716

XM_017000717

XP_005245843

XP_006710536

XP_016856205

XP_016856206

Participant Of

hasMember

input

output

hasComponent

Inferred To

KDM1A [nucleoplasm] (Bos taurus)

KDM1A [nucleoplasm] (Caenorhabditis elegans)

KDM1A [nucleoplasm] (Canis familiaris)

KDM1A [nucleoplasm] (Danio rerio)

KDM1A [nucleoplasm] (Drosophila melanogaster)

KDM1A [nucleoplasm] (Gallus gallus)

KDM1A [nucleoplasm] (Mus musculus)

KDM1A [nucleoplasm] (Plasmodium falciparum)

KDM1A [nucleoplasm] (Rattus norvegicus)

KDM1A [nucleoplasm] (Saccharomyces cerevisiae)

KDM1A [nucleoplasm] (Sus scrofa)

KDM1A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_055828.2, NP_001009999.1

ZINC - World Drugs

KDM1A_HUMAN

OpenTargets

ENSG00000004487

ZINC - FDA approved

KDM1A_HUMAN

GeneCards

O60341

ZINC - Substances

KDM1A_HUMAN

ZINC target

O60341

PRO

O60341

Orphanet

25173

ZINC - Predictions - Purchasable

KDM1A_HUMAN

HMDB Protein

HMDBP08273

PDB

2Z3Y, 5LHH, 4UV9, 2XAH, 5IT3, 5LHI, 4UVA, 2HKO, 6NR5, 4CZZ, 5LHG, 5L3E, 2EJR, 2Y48, 4UV8, 5L3D, 2H94, 6NQM, 4BAY, 2UXN, 2X0L, 5YJB, 3ZMT, 4UXN, 3ZMU, 2IW5, 3ZMS, 3ZN1, 4XBF, 2Z5U, 5H6R, 2XAJ, 5L3F, 2DW4, 2V1D, 6NQU, 2XAF, 5LBQ, 2COM, 2UXX, 3ZMV, 3ZMZ, 2XAG, 5H6Q, 3ZN0, 5LGU, 3ABT, 2XAS, 5AFW, 6E1F, 3ABU, 5L3C, 5L3B, 2L3D, 4UVB, 5L3G, 5LGN, 5LGT, 4UVC, 2XAQ, 5X60, 4KUM

Interactors (97)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.817	7
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.784	32
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.758	8
FAD [ChEBI:16238]	8	FAD [endoplasmic reticulum membrane] (R-ALL-217259) FAD [mitochondrial intermembrane space] (R-ALL-189484) FAD [mitochondrial outer membrane] (R-ALL-141707) FAD [extracellular region] (R-ALL-2160490) FAD [cytosol] (R-ALL-29386) FAD [mitochondrial matrix] (R-ALL-113596) FAD [mitochondrial inner membrane] (R-ALL-113597) FAD [peroxisomal matrix] (R-ALL-141335)	0.702	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.667	3
UniProt:O15379 HDAC3	2	Unfolded HDAC3 [cytosol] (R-HSA-6813777) HDAC3 [nucleoplasm] (R-HSA-442464)	0.649	4
UniProt:Q92769 HDAC2	2	SUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.643	6
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.641	4
UniProt:Q9NP66 HM20A			0.638	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.632	6
UniProt:Q8N0Z3 SPICE			0.621	3
UniProt:Q8N6V9 TEX9			0.621	3
UniProt:Q9BUZ4 TRAF4			0.621	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.621	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.621	3
UniProt:Q8IZ40 RCOR2			0.564	3
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [nucleoplasm] (R-HSA-157939) NICD1 [cytosol] (R-HSA-157634)	0.558	8
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.553	2
UniProt:Q13287 NMI			0.553	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.547	4
UniProt:Q9P2K3 RCOR3			0.547	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.537	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.537	3
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.527	4
UniProt:Q13330 MTA1	2	SUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537) MTA1 [nucleoplasm] (R-HSA-3465550)	0.527	4
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.508	2
UniProt:Q9NS23 RASF1			0.508	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.508	2
UniProt:Q9BQS8 FYCO1			0.508	2
UniProt:Q03181 PPARD	1	PPARD [nucleoplasm] (R-HSA-446176)	0.508	2
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.508	2
UniProt:Q8NEC7 GSTCD			0.508	2
UniProt:Q8IZU1 FAM9A			0.508	2
UniProt:Q6P047 CH074			0.508	2
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.508	2
UniProt:A5D8V7 CC151			0.508	2
UniProt:Q8TBB5 KLDC4			0.508	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.508	2
UniProt:O15198 SMAD9	3	p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) SMAD9 [cytosol] (R-HSA-201478) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441)	0.508	2
UniProt:Q8IZS5 OFCC1			0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:Q99996 AKAP9	3	p-AKAP9-BRAF fusion [cytosol] (R-HSA-6802514) AKAP9-BRAF fusion [cytosol] (R-HSA-6802267) AKAP9 [cytosol] (R-HSA-380260)	0.508	2
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.508	2
UniProt:Q9BXL8 CDCA4			0.508	2
UniProt:Q9UGK8 SRGEF			0.508	2
UniProt:Q8N6K7 SAMD3			0.508	2
UniProt:Q8N4C7 STX19			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960) GTPBP2 [extracellular region] (R-HSA-8863001)	0.508	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.508	2
UniProt:Q96JB6 LOXL4	3	LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.508	2
UniProt:Q96EY1 DNJA3			0.508	2
UniProt:P50749 RASF2			0.508	2
UniProt:Q9UBX0 HESX1			0.508	2
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.508	2
UniProt:Q96P16 RPRD1A	1	RPRD1A [nucleoplasm] (R-HSA-6814899)	0.502	2
UniProt:Q7Z4H7 HAUS6	1	HAUS6 [cytosol] (R-HSA-8855196)	0.502	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.502	2
UniProt:Q9Y466 NR2E1	1	NR2E1 [nucleoplasm] (R-HSA-376207)	0.499	2
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.499	4
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.488	2
UniProt:P38432 COIL			0.488	2
UniProt:Q9P2K3-2 RCOR3			0.488	4
UniProt:Q9Y3C0 WASC3			0.488	4
UniProt:O75564-2 O755642			0.488	2
UniProt:Q05BL1 Q05BL1			0.488	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.488	2
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.488	2
IntAct:EBI-11522976 CCDC33			0.488	2
UniProt:Q9BWT7 CAR10			0.488	2
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q9UPT5-1 EXOC7			0.488	2
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.488	2
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.488	2
UniProt:Q16236 NF2L2			0.488	2
UniProt:Q9Y250 LZTS1			0.488	2
UniProt:Q3B820 F161A			0.488	2
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.488	2
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.488	2
UniProt:Q3BBV0 NBPF1			0.488	2
UniProt:Q2M3C6 TM266			0.488	2
UniProt:Q86WH2 RASF3			0.488	2
UniProt:O15060 ZBT39			0.488	2
UniProt:Q8TC20-4 CAGE1			0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
UniProt:Q96F24 NRBF2			0.488	2
UniProt:Q96P16-3 RPRD1A			0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q9NYA3 GOG6A			0.488	2
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.488	2
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.488	2
UniProt:Q9BVG8-5 KIFC3			0.488	2
UniProt:Q49A88-3 CCDC14			0.488	2
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2 [cytosol] (R-HSA-50847) BIRC2(373-618) [cytosol] (R-HSA-202931)	0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.462	5
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.462	5