SH2B proteins bind JAK2

Stable Identifier
R-HSA-997237
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SH2B proteins bind JAK2
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The SH2B family has 3 members sharing a common domain structure, including a dimerization domain, a pleckstrin homology (PH) region, and a SH2 domain. The SH2 domain binds phosphotyrosines of various signal-transducing proteins such as c-Kit, MPL, EpoR. All are able to bind JAK2 phosphorylated at Tyr-813 (Bersenev et al. 2008, Kurzer et al. 2004, 2006), inhibiting JAK2 proliferative signaling (Gery et al. 2009).
Literature References
PubMed ID Title Journal Year
19293402 Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

Xing, H, Cao, Q, Gery, S, Koeffler, HP, Gueller, S, Tefferi, A

J Leukoc Biol 2009
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Orthologous Events
SH2B proteins bind JAK2 (Bos taurus)
SH2B proteins bind JAK2 (Canis familiaris)
SH2B proteins bind JAK2 (Danio rerio)
SH2B proteins bind JAK2 (Drosophila melanogaster)
SH2B proteins bind JAK2 (Gallus gallus)
SH2B proteins bind JAK2 (Mus musculus)
SH2B proteins bind JAK2 (Rattus norvegicus)
SH2B proteins bind JAK2 (Sus scrofa)
SH2B proteins bind JAK2 (Xenopus tropicalis)
Authored
Ouwehand, WH  (2010-11-12)
Reviewed
Akkerman, JW  (2010-10-29)
Created
Jupe, S  (2010-11-08)
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