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Dephosphorylation of STAT1 by SHP2

Stable Identifier
R-HSA-997309
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN11 [cytosol]
Physical Entity
Activity
Orthologous Events