Reactome: A Curated Pathway Database

Dephosphorylation of STAT1 by SHP2

Stable Identifier
R-HSA-997309
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of PTPN11 [cytosol] PTPN11 [cytosol] protein tyrosine phosphatase activity (0004725)
Orthologous Events