Dephosphorylation of STAT1 by SHP2

Stable Identifier
R-HSA-997309
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701.

Literature References
PubMed ID Title Journal Year
10022928 Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

You, M, Yu, DH, Feng, GS

Mol Cell Biol 1999
18508557 Protein tyrosine phosphatases in the JAK/STAT pathway

Xu, D, Qu, CK

Front Biosci 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN11 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed