Dephosphorylation of TYK2 by PTP1B

Stable Identifier
R-HSA-997311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TYK2 bears the substrate recognition motif for PTP1B, and on IFN stimulation PTP1B interacts with and dephosphorylates TYK2.
Literature References
PubMed ID Title Journal Year
11694501 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Horvath, CM, Cheng, A, Myers, MP, Barford, D, Tremblay, ML, Salmeen, A, Parisien, JP, Andersen, JN, Tonks, NK

J Biol Chem 2001
Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of PTPN1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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