Dephosphorylation of TYK2 by PTP1B

Stable Identifier
R-HSA-997311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TYK2 bears the substrate recognition motif for PTP1B, and on IFN stimulation PTP1B interacts with and dephosphorylates TYK2.

Literature References
PubMed ID Title Journal Year
11694501 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Myers, MP, Andersen, JN, Cheng, A, Tremblay, ML, Horvath, CM, Parisien, JP, Salmeen, A, Barford, D, Tonks, NK

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created