Reactome: A Curated Pathway Database

Dephosphorylation of TYK2 by PTP1B

Stable Identifier
R-HSA-997311
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TYK2 bears the substrate recognition motif for PTP1B, and on IFN stimulation PTP1B interacts with and dephosphorylates TYK2.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of PTPN1 [cytosol] PTPN1 [cytosol] protein tyrosine phosphatase activity (0004725)
Orthologous Events