Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP

Stable Identifier
R-HSA-997326
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The nuclear isoform of T cell protein tyrosine phosphatase (TC-PTP) referred as TC45 (or TC-PTPa) dephosphorylates p-STAT1 dimer in the nucleus. It can also dephosphorylate p-JAK1/3 in IFNG stimulated cells.

Literature References
PubMed ID Title Journal Year
12138178 Identification of a nuclear Stat1 protein tyrosine phosphatase

ten Hoeve, J, de Jesus Ibarra-Sanchez, M, Fu, Y, Zhu, W, Tremblay, M, David, M, Shuai, K

Mol Cell Biol 2002
11909529 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

Simoncic, PD, Lee-Loy, A, Barber, DL, Tremblay, ML, McGlade, CJ

Curr Biol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN2-1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!