Reactome: A Curated Pathway Database

Cables1 links Cdk2 and Wee-1

Stable Identifier
R-MMU-1013867
Type
Reaction
Species
Mus musculus
Compartment
Summation

In proliferating cells, Cables1 links Cdk2 and Wee1, a dual specificity kinase. Phosphorylation of Cdk2 on tyrosine-15 by Wee-1 leads to decreased Cdk2 activity; Cables1 enhances this inhibitory phosphorylation (Wu et al. 2001).

Literature References
Participants
Orthologous Events